Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing...

Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for p...

To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administration of sulpiride to freely moving rats, the levels increased, peaked at 20 min...

This study sought to determine if self-reported hypnotic depth (srHD) could be predicted from the variables of the Phenomenology of Consciousness Inventory - Hypnotic Assessment Procedure (PCI-HAP) (Pekala, 1995a, 1995b; Pekala & Kumar, 2007; Pekala et al., 2010), assessing several of the processes theorized by researchers to be associated with hypnotism: trance (altered state effects), suggest...

The present study deals with the investigation of the neurobehavioral effects of the methanolic extract of Phoenix dactylifera (PD) fruits, studied on locomotor activity, exploratory behavior, motor coordination, hot-plate test, haloperidol-induced catalepsy, sodium nitrite–induced respiratory arrest, maximum electroshock–induced convulsions using mice. The results revealed that the extract in ...

Aloe vera ( Family: Liliaceae) has been used for the treatment of diabetes, skin disorders and as anti-inflammatory agent. To evaluate the anti-parkinson effect, Rota rod and catalepsy bar models were used. Assessment of oxidative stress was done in the striatal region of the brain by malondialdehyde (MDA) and reduced glutathione (GSH) measurement. A.vera (200 and 400 mg/kg, p.o.) was found to ...