نتایج جستجو برای: ژن tcda

تعداد نتایج: 16022  

Journal: :The Journal of biological chemistry 2014
Peter Orth Li Xiao Lorraine D Hernandez Paul Reichert Payal R Sheth Maribel Beaumont Xiaoyu Yang Nicholas Murgolo Grigori Ermakov Edward DiNunzio Fred Racine Jerzy Karczewski Susan Secore Richard N Ingram Todd Mayhood Corey Strickland Alex G Therien

The symptoms of Clostridium difficile infections are caused by two exotoxins, TcdA and TcdB, which target host colonocytes by binding to unknown cell surface receptors, at least in part via their combined repetitive oligopeptide (CROP) domains. A combination of the anti-TcdA antibody actoxumab and the anti-TcdB antibody bezlotoxumab is currently under development for the prevention of recurrent...

2013
Imane El Meouche Johann Peltier Marc Monot Olga Soutourina Martine Pestel-Caron Bruno Dupuy Jean-Louis Pons

Clostridium difficile intestinal disease is mediated largely by the actions of toxins A (TcdA) and B (TcdB), whose production occurs after the initial steps of colonization involving different surface or flagellar proteins. In B. subtilis, the sigma factor SigD controls flagellar synthesis, motility, and vegetative autolysins. A homolog of SigD encoding gene is present in the C.difficile 630 ge...

2009
S. Alvarez-Perez

Clostridium difficile is considered an important uncontrolled cause of neonatal diarrhea. Also, the presence of bacteria in the feces of the animal could represent a zoonosic risk for the contamination of meat products. Therefore, it is necessary to have procedures available for the early detection of C. difficile in animals. The current study describes a new semi-automated procedure for the re...

2012
Citlaly Medrano Mariana Boadella Hugo Barrios Antonio Cantú Zeferino García José de la Fuente Christian Gortazar

Molecular typing analysis showed that both case-patients had a monoclonal infection caused by C. diffi cile ribotype 027. Both isolates had tcdA, tcdB, and cdtB and had a deletion in tcdC (data not shown). In summary, the described severe cases of C. diffi cile infection in Chile were caused by epidemic C. diffi cile ribotype 027. One of these casepatients required urgent colectomy. These resul...

Journal: :Journal of Entomological Society of Iran 2023

وراثت مقاومت سفیدبالک گلخانه، Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae)، به دو ترکیب ایمیداکلوپرید و کلرپایریفوس مورد مطالعه قرار گرفت. در این پژوهش، از جمعیت فیلستان ورامین (FL) عنوان والد مقاوم فردیس کرج (FR) حساس استفاده شد. مقدار ترتیب حدودا 62/13 91/14 برابر بود. عدم وجود اختلاف معنی‌دار LC50 روی تلاقی‌های F1 (R♂×S♀) Fʹ1 (R♀×S♂) نشان داد که T. نوع اتوزومی (غیرجنسی) است. ه...

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