The postsynaptic density (PSD) is crucial for synaptic functions, but the molecular architecture retaining its structure and components remains elusive. Homer and Shank are among the most abundant scaffolding proteins in the PSD, working synergistically for maturation of dendritic spines. Here, we demonstrate that Homer and Shank, together, form a mesh-like matrix structure. Crystallographic an...

The Homer help desk support system, developed in the course of the Inreca-II project, is an example of applying Case-Based Reasoning to problems of a software-intensive organization. This paper discusses, in retrospect, Homer with respect to change management processes at DaimlerChrysler and various feedback and learning possibilites that the help desk support system provided for itself, the he...

One of the most frustrating aspects of Homeric studies is that so little literary material outside the Homeric corpus itself survives to enhance our understanding of the cultural landscape of the period. Recent scholarship suggests that a large and diverse poetic tradition lay behind the figure we refer to as "Homer," but little of it survives. Indeed we have little continuous written Greek for...

Introduction:The purpose of this study was to define the etiologies of Horner syndrome in the pediatric population. Methods: A retrospective review was performed of the medical records of all pediatric Horner syndrome patients (<18 years old) examined by the pediatric ophthalmology services at two large referral centers. Results: Seventythree pediatric Horner syndrome patients were identified. ...

Activation of group I metabotropic glutamate (mGlu) receptors recruits the endocannabinoid system to produce both short- and long-term changes in synaptic strength in many regions of the brain. Although there is evidence that the endocannabinoid 2-arachidonoylglycerol (2-AG) mediates this process, the molecular mechanism underlying 2-AG mobilization remains unclear. In the present study, we use...

HOMER, the Human Oriented MEssenger Robot, is a stereovision guided mobile robot for performing human-interactive tasks. Our design concept for HOMER combines mobile robotic techniques for navigation, localization, map building and obstacle avoidance with human interaction capacities for person recognition, speech, facial expression and gesture recognition, and human dynamics modeling. HOMER’s ...

Long Homer proteins forge assemblies of signaling components involved in glutamate receptor signaling in postsynaptic excitatory neurons, including those underlying synaptic transmission and plasticity. The short immediate-early gene (IEG) Homer1a can dynamically uncouple these physical associations by functional competition with long Homer isoforms. To examine the consequences of Homer1a-media...

A virtual training system has been developed to train novice surgeons on using the new jig and fixture in a knee replacement surgery. In this study, we described how a virtual hand was employed in a Virtual Knee Replacement Surgery Training System. The virtual hand is equipped with HOMER-G, a selection and manipulation technique that combines the Arm-extension and Ray-casting technique for easy...

I offer a reading of the Diapeira episode based on the semantics and thematics of akhos. My findings resolve a crux at 2.171, where Homer identifies akhos as the reason Odysseus is not launching his ship. Homer clearly signposts the nature of Odysseus' akhos as grief over loss of time in Athene's subsequent speech to him, but the reference is proleptic and has consequently eluded the

Since 1986, antiretroviral therapy (ART) has been available free of charge to individuals living with HIV in British Columbia (BC), Canada, through the BC Centre of Excellence in HIV/AIDS (BC-CfE) Drug Treatment Program (DTP). The Highly Active Antiretroviral Therapy (HAART) Observational Medical Evaluation and Research (HOMER) cohort was established in 1996 to maintain a prospective record of ...