Human epidydimis secretory protein 4 is an 11kDa protein, which is localized on chromosome 20q12 (Schummer et al., 1999). For the first it was identified in epidydimis epithelium and its function was initially associated with the maturation of sperm involved in protease inhibition (Kirchhoff et al., 1998). Human epidydimis secretory proteins in the cell can be found in the cytoplasm perinuclear...

BACKGROUND Struma ovarii is a rare ovarian teratoma with non-specific clinical presentation that can mimic malignancy, especially when combined with the presence of ascites. Since the surgical procedures performed for benign and malignant tumors are quite different, pre-operative differential diagnosis is key. In this case report we compare the levels of biomarkers CA 125 and HE4 in the differe...

In screening for epithelial ovarian cancer, unnecessary surgery can be reduced by limiting use of transvaginal ultrasound (TVU) to women with increasing CA125 serum levels. Replacing or augmenting TVU with measurement of a serum marker specific for malignancy might further improve screening performance. Serum samples from 112 invasive ovarian cancer patients and 706 matched control subjects fro...

The aim of our study was to assess the value of a preoperative He4-serum-assay and ROMA-score assessment in improving the accuracy of frozen section histology in the diagnosis of borderline ovarian tumors (BOT). 113 women presenting with a unilateral ovarian mass diagnosed as serous/mucinous BOT at frozen-section-histology (FS) and/or confirmed on final pathology were recruited. Pathologists we...

Abstract Background Inadequacy of effective sensitive and specific screening modalities results in late-stage diagnosis ovarian cancer. Cancer Antigen-125 (CA-125) individually possesses limited specificity for differentiating adnexal masses. The present study aimed to evaluate the Human Epididymis Protein 4 (HE4), Risk Ovarian Malignancy Algorithm (ROMA), Index (RMI) ameliorating sensitivity b...

Breast and ovarian cancers account for approximately 55,000 deaths each year in the United States [1]. Both tumor types exhibit morphologic and molecular heterogeneity; each with multiple histologic subtypes that differ significantly in their prognosis and response to therapy. The recent characterization of breast and ovarian cancers by The Cancer Genome Atlas (TCGA) revealed that high-grade se...

We report on the measurement of beam spin asymmetry in deeply virtual Compton scattering off He4 using CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab a 6 GeV longitudinally polarized electron incident pressurized gaseous target. detail method used to ensure exclusivity measured reactions, particular upgrade CLAS with radial time projection chamber detect low-energy recoiling nuclei...

Các xét nghiệm CA125 và HE4 được chỉ định phổ biến trong chẩn đoán ung thư buồng trứng, mỗi có vai trò khác nhau theo dõi điều trị. ROMA test (Risk of Ovarian Malignancy Algorithm) là một số dựa trên thuật toán kết hợp quả của HE4, đi kèm với tình trạng kinh nguyệt, để từ đó đánh giá khả năng mắc trứng. Trong nghiên cứu này chúng tôi xem trị trứng phụ nữ khối u ở vùng chậu đến khám tại Bệnh việ...