نتایج جستجو برای: ژن hdac4

تعداد نتایج: 16335  

Journal: :Journal of Cell Biology 2011

Journal: :European Heart Journal 2022

Abstract Introduction Accumulation of senescent endothelial cells with age is an important driver vascular aging and related cardiovascular disease. However, little known about the mechanisms signaling pathways that underpin cell senescence. Aquaporin-1 (AQP1) has been implicated in sensing hydrogen peroxide (H2O2), which differentially modulates signal transduction. Nonetheless, role AQP1 regu...

Journal: :Cell 2004
Bruce A. Hug

RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.

2012
Robert S. Haworth Konstantina Stathopoulou Alexandra J. Candasamy Metin Avkiran

Rationale: Myocyte enhancer factor 2 (MEF2) transcription factors drive the genetic reprogramming that precipitates pathological cardiac hypertrophy and remodeling. Class II histone deacetylase (HDAC) isoforms, such as HDAC5, act as signal-responsive repressors of MEF2 activity in cardiac myocytes and their nuclear export provides a key mechanism for the neurohormonal induction of such activity...

Journal: :Cell 2011
Maria M. Mihaylova Debbie S. Vasquez Kim Ravnskjaer Pierre-Damien Denechaud Ruth T. Yu Jacqueline G. Alvarez Michael Downes Ronald M. Evans Marc Montminy Reuben J. Shaw

Class IIa histone deacetylases (HDACs) are signal-dependent modulators of transcription with established roles in muscle differentiation and neuronal survival. We show here that in liver, class IIa HDACs (HDAC4, 5, and 7) are phosphorylated and excluded from the nucleus by AMPK family kinases. In response to the fasting hormone glucagon, class IIa HDACs are rapidly dephosphorylated and transloc...

2017
Zephan Melville Erick O Hernández-Ochoa Stephen J P Pratt Yewei Liu Adam D Pierce Paul T Wilder Kaylin A Adipietro Daniel H Breysse Kristen M Varney Martin F Schneider David J Weber

Biochemical and structural studies demonstrate that S100A1 is involved in a Ca2+-dependent interaction with the type 2α and type 2β regulatory subunits of protein kinase A (PKA) (RIIα and RIIβ) to activate holo-PKA. The interaction was specific for S100A1 because other calcium-binding proteins (i.e., S100B and calmodulin) had no effect. Likewise, a role for S100A1 in PKA-dependent signaling was...

Journal: :Cell 2008
Tetsuro Ago Tong Liu Peiyong Zhai Wei Chen Hong Li Jeffery D. Molkentin Stephen F. Vatner Junichi Sadoshima

Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death. Here we studied the molecular mechanism by which Trx1 attenuates cardiac hypertrophy. Trx1 upregulates DnaJb5, a heat shock protein 40, and forms a multiple-protein complex with DnaJb5 and class II histone deacetylases (H...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
T A McKinsey C L Zhang E N Olson

Skeletal muscle differentiation is controlled by interactions between myocyte enhancer factor-2 (MEF2) and myogenic basic helix-loop-helix transcription factors. Association of MEF2 with histone deacetylases (HDAC) -4 and -5 results in repression of MEF2 target genes and inhibition of myogenesis. Calcium/calmodulin-dependent protein kinase (CaMK) signaling promotes myogenesis by disrupting MEF2...

Journal: :International journal of oncology 2010
Mee Young Ahn Hae Young Chung Wahn Soo Choi Byung Mu Lee Sungpil Yoon Hyung Sik Kim

Histone deacetylase (HDAC) inhibitors are a new class of anticancer agents that act by inhibiting cancer cell proliferation and inducing apoptosis both in vitro and in vivo. This study examined the anti-tumor effect of apicidin on human endometrial cancer Ishikawa cells in an animal model by inhibiting specific HDAC expression. Nude mice were injected subcutaneously (s.c.) with Ishikawa cells, ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Shinsuke Fujii Patrick Emery Hubert Amrein

The physiology and behavior of many organisms are subject to daily cycles. In Drosophila melanogaster the daily locomotion patterns of single flies are characterized by bursts of activity at dawn and dusk. Two distinct clusters of clock neurons-morning oscillators (M cells) and evening oscillators (E cells)-are largely responsible for these activity bursts. In contrast, male-female pairs of fli...

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