Growth hormone (GH), acting through its receptor (GHR), is essential for somatic growth and development and maintaining metabolic homeostasis. GHR gene deficient (GHR) mice exhibit drastically diminished IGF-I levels, proportional growth retardation, elevated insulin sensitivity and reduced islet β-cell mass. Unlike the liver which is mostly unaffected by changes in the IGF-I level, skeletal mu...

In the present study, primary mouse hepatocytes from 8- to 10-week-old virgin female Swiss-Webster mice were perfused with collagenase (100 U/ml) using the two-step method. Isolated hepatocytes were plated in a rat tail type I collagen sandwich configuration to examine the regulation of GH receptor (GHR) and GH-binding protein (GHBP) expression by GH and 17beta-estradiol (E2). After 48 h of ini...

Growth Hormone is essential for the regulation of growth and the homeostatic control of intermediary metabolism. GH actions are mediated by the Growth Hormone Receptor; a member of the cytokine receptor super family that signals chiefly through the JAK2/STAT5 pathway. Target tissue responsiveness to GH is under regulatory control to avoid excessive and off-target effects upon GHR activation. Th...

Children with cholestatic liver diseases, in particular biliary atresia, may develop an acquired growth hormone (GH) resistance. This is characterized by normal GH secretion, reduced liver GH receptor (GHR) abundance, and reduced circulating insulin-like growth factor I (IGF-I). Consequences include linear growth failure, reduced muscle mass, and increased perioperative morbidity and mortality....

CONTEXT Human growth hormone receptor (GHR) transcripts have two isoforms, full-length (GHRfl) or exon 3 deleted (GHRd3). An association of these isoforms has been found with small for gestational age (SGA) infants but does not influence adult height. The role of this polymorphism in the birth size spectrum in the general population is unclear. OBJECTIVE To determine the association of matern...

have generated two independent dwarf mouse lines with decreased GH action; however, only one has extended longevity. Why? Decreased signaling through the GH/IGF-1 axis in vertebrates, or comparable pathways in invertebrates, has repeatedly been shown to extend lifespan. A prominent example is mice with a disruption in the GH receptor gene (GHR-/-) generated in our laboratory two decades ago [1]...

Increasing evidence suggests that GH is important in normal mammary gland development. To investigate this further, we studied the distribution and levels of growth hormone receptor (GHR) and GH-binding protein (GHBP) in the mouse mammary gland. At three weeks of age, the epithelial component of the right fourth inguinal mammary gland of female mice was removed. These animals were then either m...

In this paper, the inclinometer is used to control the balance of a humanoid robot on a miniature surfboard. GHR (Griffith University Humanoid Robot) is the humanoid robot developed in the Robotics and Games laboratory, at Griffith University. In order to measure the angle of the inclining surfboard, the inclinometer is attached to the back of the right foot of the GHR. To remove the high frequ...

BACKGROUND We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without agoraphobia, and to compare these parameters before and after treatment. SUBJECTS AND METHODS The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 p...

GH participates in growth, metabolism, and cellular differentiation. To study these roles, we previously generated two different dwarf mouse lines, one expressing a GH antagonist (GHA) and the other having a disrupted GH receptor and binding protein gene (GHR -/-). In this study we compared the two dwarf lines in the same genetic background (C57BL/6J). One of the most striking differences betwe...