نتایج جستجو برای: ژن cyp1b1

تعداد نتایج: 16752  

Journal: :Carcinogenesis 2003
David C Spink Barbara H Katz Mirza M Hussain Brian T Pentecost Zhimin Cao Barbara C Spink

Cytochrome P450 (CYP)1A1 and CYP1B1, which are under the regulatory control of the aryl hydrocarbon (Ah) receptor (AhR), catalyze the metabolic activation of numerous procarcinogens and the hydroxylation of 17beta-estradiol (E2) at the C-2 and C-4 positions, respectively. There is evidence of cross-talk between estrogen receptor alpha (ERalpha)- and AhR-mediated signaling in breast and endometr...

2013

The claim that CYP1B1 is a universal tumour marker protein rests on the evidence in at least fifteen peer-reviewed research or review papers published since 1997. The first evidence was published in 1997 by Professor Burke’s research team at Aberdeen University, who showed, using standard pathology immunohistochemical techniques backed up by biochemical Western blotting methodology, that CYP1B1...

Journal: :Molecular cancer research : MCR 2006
Tristan M Sissung Douglas K Price Alex Sparreboom William D Figg

Several of the hormone-mediated cancers (breast, endometrial, ovarian, and prostate) represent major cancers in both incidence and mortality rates. The etiology of these cancers is in large part modulated by the hormones estrogen and testosterone. As advanced disease develops, the common treatment for these cancers is chemotherapy. Thus, genes that can alter tissue response to hormones and alte...

Journal: :The Journal of biological chemistry 1997
Y Y Wo J Stewart W F Greenlee

Our laboratory has cloned the cDNA (Sutter, T. R., Tang, Y. M., Hayes, C. L., Wo, Y.-Y. P., Jabs, E. W., Li, X., Yin, H., Cody, C. W. , and Greenlee, W. F. (1994) J. Biol. Chem. 269, 13092-13099) and gene (Tang, Y. M., Wo, Y.-Y. P., Jabs, E. W., Stewart, J. C., Sutter, T. R., and Greenlee, W. F. (1996) J. Biol. Chem. 271, 28324-28330) for human CYP1B1, a new member of the cytochrome P450 superf...

Journal: :Molecular Vision 2009
Mei Yang Xiangming Guo Xing Liu Huangxuan Shen Xiaoyun Jia Xueshan Xiao Shiqiang Li Shaohua Fang Qingjiong Zhang

PURPOSE This study was conducted to investigate the mutation spectrum of the cytochrome P450 gene (CYP1B1) in Chinese patients with primary congenital glaucoma (PCG). METHODS The coding regions of CYP1B1 from 41 Chinese PCG patients were analyzed using polymerase chain reaction (PCR) and heteroduplex analysis-single strand conformation polymorphism (HA-SSCP) followed by subsequent cloning and...

2003
Y Ohtake T Tanino Y Suzuki H Miyata M Taomoto N Azuma H Tanihara M Araie Y Mashima

Aim: To investigate the phenotypes associated with cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma (PCG). Methods: 66 Japanese patients with PCG were screened for sequence mutations in the CYP1B1 gene using single strand conformation polymorphism analysis followed by automated DNA sequencing. 11 cases had a CYP1B1 mutation in both alleles (the mu...

Journal: :Cancer research 2003
Sheila Dawling Nady Roodi Fritz F Parl

Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. Catechol-O-methyltransferase catalyzes the methylation of catechol estrogens to methoxyestrogens (2-MeOE2, 2-OH-3-MeOE2, and 4-MeOE2), which simultaneously lowers the potential for DNA damage and ...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2005
Jun Gao Fredine T Lauer Sandy Dunaway Scott W Burchiel

7,12-Dimethylbenz(a)anthracene (DMBA) is a potent carcinogen that induces immunosuppression of both humoral and cell-mediated immunity in mice and other species. Previous studies have shown that CYP1B1 is required for bone marrow toxicity produced by DMBA in mice. Therefore, the purpose of these studies was to determine whether CYP1B1 was required for spleen cell immunotoxicity. Female C57BL/6N...

2007
Arun Kumar Manjunath G. Basavaraj Santosh K. Gupta Imteyaz Qamar Abdullah Mahmood Ali Vineeta Bajaj T.K. Ramesh D. Ravi Prakash Jyoti S. Shetty Syril K. Dorairaj

PURPOSE Mutations in the CYP1B1, MYOC, OPTN, and WDR36 genes result in glaucoma. Given its expression in the optic nerve, it is likely a mutation in the OPTC gene is also involved in initiating glaucoma. This study was designed to evaluate the involvement of the CYP1B1, MYOC, OPTN, and OPTC genes in the etiology of adult-onset primary open-angle glaucoma (POAG) found in 251 Indian patients. M...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005
Wanqing Wen Qiuyin Cai Xiao-Ou Shu Jia-Rong Cheng Fritz Parl Larry Pierce Yu-Tang Gao Wei Zheng

Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are important estrogen-metabolizing enzymes and, thus, genetic polymorphisms of these enzymes may affect breast cancer risk. A population-based case-control study was conducted to assess the association of breast cancer risk with CYP1B1 and COMT polymorphisms. A meta-analysis was done to summarize the findings from this and pr...

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