Because of the synergy seen in adult trials when 5-fluorouracil is combined with leucovorin, we initiated a Phase I trial of this combination in children's refractory cancer. Leucovorin, an equal mixture of the (6R,S)-diastereoisomers, was administered p.o. for 6 consecutive days as 4 equal doses at 0, 1, 2, and 3 h totaling 500 mg/m2/day. 5-Fluorouracil was given daily on days 2 to 6 as an i.v...

It has been suggested that an inhibitory ECM containing chondroitin-6-sulfate proteoglycan (C-6S-PG) and tenascin (TN), which appears homogeneously in the core of the OB following afferent fiber arrival, helps position ingrowing olfactory axons in the prospective glomerular layer (GL) (Gonzalez and Silver, 1992; Gonzalez et al., 1993). Later, a similar ECM associated with astrocytes envelopes a...

BACKGROUND Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, (R,S)-ketamine is extensively metabolized and the contribution of its metabolites to increased mTOR signaling is unknown. MET...

The pharmacokinetics of daikenchuto (TJ-100), a pharmaceuticalgrade traditional Japanese medicine, were investigated in healthy Japanese volunteers after a single oral administration of 2.5-, 5-, and 10-g doses. Six ingredients [hydroxy-sanshool (HAS), hydroxy-sanshool (HBS), [6]-shogaol (6S), [10]-shogaol (10S), ginsenoside Rb1(GRB1), and ginsenoside Rg1(GRG1)] of TJ-100 were determined by usi...

The pharmacokinetics of daikenchuto (TJ-100), a pharmaceuticalgrade traditional Japanese medicine, were investigated in healthy Japanese volunteers after a single oral administration of 2.5-, 5-, and 10-g doses. Six ingredients [hydroxy-sanshool (HAS), hydroxy-sanshool (HBS), [6]-shogaol (6S), [10]-shogaol (10S), ginsenoside Rb1(GRB1), and ginsenoside Rg1(GRG1)] of TJ-100 were determined by usi...

We constructed population pharmacokinetic (PK) models for the five constituents of daikenchuto (DKT), a traditional Japanese herbalmedicine. Data were collected from two randomized PK studies conducted in Japan and the United States. Participants received single oral doses of 2.5 g, 5 g, and 10 g of DKT. The plasma concentrations of five DKT constituents—hydroxy-a-sanshool (HAS), hydroxyl-bsans...

2014 A possible way to calibrate the Cesium 6S ~ 7S parity violating electric dipole amplitude E1 (p.v) is to make use of the ratio E1 (p.v )/M1 (h.f ) where M1 (h.f ) is the magnetic dipole amplitude induced by the hyperfine interaction V (h.f). We show by evaluating relativistic and many-body effects that M1 (h.f) is given, to better than 3.10-3, by the geometrical mean of the 6S and 7S hyper...

We carry out relativistic many-body calculations of the static and dynamic dipole polarizabilities of the ground 6s2 S0 and the first excited 6s6p P0 states of Yb. With these polarizabilities, we compute several properties of Yb relevant to optical lattice clocks operating on the 6s2 S0–6s6p P0 transition. We determine (i) the first four magic wavelengths of the laser field for which the freque...