Abstract Background A variety of management options (e.g. immunotherapies, lifestyle interventions, and rehabilitation) are available for people with relapsing-remitting multiple sclerosis (RRMS). Besides coping the diagnosis, MS (pwMS) have to make complex decisions such as deciding about immunotherapies. In addition factual information, reports patient experiences (PEx) may support patients i...

Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix metalloproteinase-9 (MMP-9), and a cell-signaling receptor. In the peripheral nervous system (PNS), LRP-1 is robustly expressed by Schwann cells only after injury. Herein, we demonstrate that MMP-9 activates extracellular-signal-regulated kinase (ERK1/2) and Akt in Schwann ce...

Atypical hemolytic uremic syndrome (aHUS) is a rare, lifethreatening systemic inflammatory disease that presents classically with microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury.1 Extra renal manifestations are observed in 20% of patients.2 A 42-year-old woman with unremarkable past medical history presented in our hospital reporting a 6-day history of headache, naus...

Introduction: Parallel spatially selective EXcitation (PEX) relies on an exact matching of RF pulses and a simultaneously traversed k-space trajectory. However, e.g. eddy currents or gradient amplifier bandwidth limitations may lead to deviations of the traversed trajectory resulting in reduced excitation accuracy due to the susceptibility of PEX pulses to trajectory errors [1]. Therefore, diff...

Particles in exhaled air (PEx) may reflect the composition of respiratory tract lining fluid (RTLF); thus, there is a need to assess their potential as sources of biomarkers for respiratory diseases. In the present study, we compared PEx from patients with asthma and controls using time-of-flight-secondary ion mass spectrometry (TOF-SIMS) and multivariate analysis. Particles were collected usin...

Pectus excavatum (PEX) is the most frequent congenital deformity of the anterior chest wall. Few studies have classified the degree of anatomical distortion in an objective manner. Our objective was to present two new clinical and original methods for evaluation of PEX deformity developed in our service (chest cyrtometry and anthropometric index) that are simple and easily applicable in the off...

The Satisfiability Modulo Theories solver Z3 [10] is used in several program analysis and verification tools at Microsoft Research. Some of these tools require bit-precise reasoning for accurately modeling machine arithmetic instructions. But this alone is rarely sufficient, and an integration with other theories is required. The Pex tool [20] performs program exploration of .NET programs by ge...

Abstract Background Plasma exchange (PEX) has been the primary treatment for immune-mediated thrombotic thrombocytopenic purpura (iTTP) since 1990s. Daily PEX is recommended in international guidelines, but was only reimbursed up to three times weekly under Japanese national health insurance system until March 2018. This study conducted analyze practice patterns and outcomes patients with TTP J...

BACKGROUND Currently, there are no effective medical treatment options to prevent the formation of heterotopic bones in fibrodysplasia ossificans progressiva (FOP). By the drug repositioning strategy, we confirmed that perhexiline maleate (Pex) potentially ameliorates heterotopic ossification in model cells and mice. Here, we conducted a prospective study to assess the efficacy and safety of Pe...