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هدف: هدف پژوهش حاضر، ساخت و اعتبار­سنجی سیاهه آسیب‌شناسی روانشناختی نوجوانان در فضای مجازی بود. روش: روش آمیخته اکتشافی (کیفی-کمی) بدین منظور با استفاده از تحلیل مضمون مقالات مصاحبه‌های انجام‌شده متخصصان فعال مجازی، آسیب­ ها شناسایی شدند بر اساس آن ­ای ساخته شد. جامعه آماری بخش کیفی شامل مقالات، اساتید دانشگاه­ های اراک، اصفهان، امام خمینی قزوین شهر اراک بودند که نمونه هدفمند آنها انتخاب کمی بو...

Volume 99 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 98 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 97 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Resear...

Volume 99 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 98 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 97 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Resear...

This review will focus on our current state of understanding of the cellular and molecular mechanisms by which CsA exerts immunosuppression and will present new information on: pharmacokinetic variability of CsA, selection of specimen and method for measuring CsA concentration, identity of CsA metabolites and their immunosuppressive and toxic activity, and the relationship between steady-state ...

When converting maintenance renal allograft recipients from Sandimmune (cyclosporin A [CsA]) to Neoral (CsA-microemulsion [CsA-ME]), a dose conversion ratio of 1:1 may not be optimal, in part because of the variability in absorption of the CsA formulation of cyclosporine. After conversion using a 1:1 dose ratio, an individualized approach to the management of dosing was applied. In this article...

PURPOSE Topical preparations of cyclosporine (CsA) are common therapeutics for the treatment of dry eye. However, they are not devoid of side effects, such as allergy and irritation. The present study aimed at evaluating the safety profile of a new CsA formulation in cationic emulsion (CEm) in vitro with a dynamic corneal wound healing assay using human corneal epithelial (HCE) cells, and in vi...

M.J. Korstanje, Department of Dermatology, Academic Hospital Maastricht, PO Box 1918, NL–6201 BX Maastricht (The Netherlands) The effectiveness of ciclosporin (CsA) in severe plaque psoriasis is established [1. 2]. However. CsA may not be randomly used in clinical practice because of its side effects, which include hepatotoxicity. acute and chronic nephrotoxicity, hirsutism. hypertension and to...

OBJECTIVES The objectives of this study were to prepare cyclosporin A (CsA)-containing proliposomes using the supercritical antisolvent (SAS) process and the conventional thin film method for the comparative study of proliposomal formulations and to evaluate the physicochemical properties of these proliposomes. METHODS CsA-containing proliposomes were prepared by the SAS process and the conve...