The peripheral astrocyte process (PAP) preferentially associates with the synapse. The PAP, which is not found around every synapse, extends to or withdraws from it in an activity-dependent manner. Although the pre- and postsynaptic elements have been described in great molecular detail, relatively little is known about the PAP because of its difficult access for electrophysiology or light micr...

Background-We compared the hemodynamic responses to inhibition or stimulation of endothelial nitric oxide (NO) release of isolated explanted lungs from transplantation recipients with pulmonary hypertension and in normotensive unallocated donor lungs. Methods and Results-Lungs from 10 patients with severe pulmonary hypertension (SPH) and from 16 patients with severe chronic obstructive lung dis...

RATIONALE Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activat...

background: cervical cancer is the second most common cancer among women in the world and the most common cancer in developing countries. secondary prevention, achieved through pap smear testing, is the single most effective tool in reducing deaths due to cervical cancer. the aim of this study was to determine factors affecting the belief to obtain a regular pap smear test among women based on ...

conclusion our results showed that obtained protein patterns of the isolated strains were more reliable than serotyping results for typing purposes. our findings indicated that pap adhesion–encoding operon has an important role in the development and severity of uti. many cases of serious urogenital diseases are caused by a limited number of uropathogenic e.coli strains that generally possess s...

Background—Characteristics of patients with idiopathic pulmonary arterial hypertension (IPAH) who benefit from long-term calcium channel blockers (CCB) are unknown. Methods and Results—Acute pulmonary vasodilator testing with epoprostenol or nitric oxide was performed in 557 IPAH patients. Acute responders, defined by a fall in both mean pulmonary artery pressure (PAP) and pulmonary vascular re...

BACKGROUND Cervical intra-epithelial neoplasia (CIN) and cervical cancer remain important health problems for women worldwide. It is largely a preventable disease that is characterised by a long lead time. The objective of this study was to determine the frequency of precancerous conditions of cervix (CIN I-III) in women with chronic vaginal discharge by Pap smear screening. METHODS The study...

Poly(A) polymerase (PAP) plays an essential role in polyadenylation of mRNA precursors, and it has long been thought that mammalian cells contain only a single PAP gene. We describe here the unexpected existence of a human PAP, which we call neo-PAP, encoded by a previously uncharacterized gene. cDNA was isolated from a tumor-derived cDNA library encoding an 82.8-kDa protein bearing 71% overall...