نتایج جستجو برای: پیرازولیدین 5

تعداد نتایج: 1215768  

Journal: :Journal of Optical Communications 2015

2013
G. Klimke R. Mengel M. J. Robins

Adenosine Analogs, Conformation, NMR The solution conformation of adenosine(/Oribosides modified at the 2', 3' or 5' position is derived from the analysis o f the HRNM R spectra of the ribose protons. The conformational equilibria of the furanoside rings are described by the two state N <-+ S model introduced by Altona and Sundaralingam. The new compounds studied are: 2'-thiobenzoyl-2'-deoxyade...

Journal: :Cytogenetic and genome research 2015
Duo Li Bin Guo Haijing Wu Lina Tan Qianjin Lu

DNA methylation plays an important role in the epigenetic regulation of mammalian gene expression. TET (ten-eleven translocation) proteins, newly discovered demethylases, have sparked great interest since their discovery. TET proteins catalyze 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in 3 consecutive Fe(II)- and 2-oxoglutarate (2-OG)-dependent oxidati...

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Neurobiology of aging 2014
Daniel Condliffe Andrew Wong Claire Troakes Petroula Proitsi Yogen Patel Leonidas Chouliaras Cathy Fernandes Jonathan Cooper Simon Lovestone Leonard Schalkwyk Jonathan Mill Katie Lunnon

Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethyl...

2014
Sonja C. Brooks Robert L. Fischer Jin Hoe Huh Brandt F. Eichman

Methylation of cytosine to 5-methylcytosine (5mC) is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing. Active demethylation in animals is believed to proceed by DNA glycosylase removal of deaminated or oxidized 5mC. In plants, 5mC is removed from the genome directly by the DEMETER (DME) family of DNA glycosylases. Arabidopsis thaliana DME excis...

Journal: :Revista Científica FAEMA 2017

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

2013
Daniel Renciuk Olivier Blacque Michaela Vorlickova Bernhard Spingler

5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures of four variants of the d(CGCGAATTCGCG) dodecamer, containing either 5-hmC or 5-methylcytosine (5-mC) at position 3...

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