The cardiovascular responses to passive limb movement (PLM) at the knee are well established, however, responses to PLM at other joints involving smaller muscle volume are unknown. To compare the cardiovascular responses to passive movement at other joints, 10 participants underwent a PLM protocol in which the wrist, elbow, ankle, and knee joints were passively extended and flexed at 1 Hz for 1...

BENEFITS  Enables manufacturers to manage complex product development activities across organizations, suppliers, and customers  Special suitability for enterprises in the range of manufacturing, machine and equipment construction and automotive supplier  Encapsulates a comprehensive understanding of the product engineering process for Industrial Manufacturing.  By focusing on specific aspe...

Two subjects presented with periodic leg movement (PLM) syndrome during sleep that was characterized by marked sleep fragmentation and repetitive short central apnoeas. Treatment of PLM using Clonazepam, a benzodiazepine with hypnotic properties, markedly reduced the sleep fragmentation due to PLM and, despite its depressant properties on the central nervous system, controlled the repetitive ce...

The goal of this study was to gain an understanding of how companies in various industry sectors handled the migration of product data and the implementation of a PDM tool within the scope of a larger PLM environment. Ten companies were examined regarding their implementation process relative to PDM and PLM toolsets. Relevant sources from within each company were interviewed to gather informati...

Mathematical competence requires pattern recognition for appropriate application of concepts and procedures. Research demonstrates that interventions targeting perceptual learning (PL) improve math performance. Little research, however, has directly investigated encoding changes, measured psychophysically, that may accompany PL gains in real-world tasks. We sought evidence of lasting encoding c...

The basis for Sustainable PLM is enabling Intelligent Products to communicate between themselves and with other systems in order to reduce CO2 emissions, energy usage and environmental damage. This type of communication between Intelligent Products and other information systems with the objective of reducing environmental impacts is an example of closed-loop product lifecycle management. The ob...

Competitive success of manufacturing firms is by and large determined by the success of the products they introduce to the market. This is why companies continuously try to improve the efficacy of their product realization process. Product Lifecycle Management (PLM) is a business solution which aims to streamline the flow of information about the product and related processes throughout the pro...

The advent of the product lifecycle management (PLM) system provides a Web-based IT platform that streamlines new product development (NPD) related processes by closely integrating the project team and the broader organization. However, there is a lack of systematic research on the use of PLM for better NPD management. The adaptation process for new technology is not yet well understood. This s...

Phospholemman (PLM) or FXYD1 is a major cardiac myocyte phosphorylation target upon adrenergic stimulation. Prior immunoprecipitation and functional studies suggest that phospholemman associates with the Na/K-pump (NKA) and mediates adrenergic Na/K-pump regulation. Here, we tested whether the NKA-PLM interaction is close enough to allow fluorescence resonance energy transfer (FRET) between cyan...