نتایج جستجو برای: پمپ acrab

تعداد نتایج: 1905  

بهزاد سلیمیان ریزی مجتبی طحانی محمد حسن شجاعی فرد مهدی بگلری میربیوک احقاقی هادی فلاح

عملکرد پمپ های گریز از مرکز هنگام پمپاژ سیالات لزج به شدت افت پیدا می­کند. این افت می­تواند با تعویض چرخ متحرک اصلی پمپ گریز از مرکز بهبود پیدا کند. جایگزینی چرخ متحرک پمپ نسبت به تعویض کل پمپ بسیار مقرون به صرفه می­باشد. در مطالعه پیش رو تأثیرات زاویه خروجی پره و پهنای پاساژ چرخ متحرک بر روی عملکرد پمپ گریز از مرکز هنگام انتقال یک روغن خاص، به صورت تجربی و عددی بررسی شده است. به کمک یک دستگاه ...

2015
Henrietta Venter Rumana Mowla Thelma Ohene-Agyei Shutao Ma

Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance in the presence of an active efflux pump. The substrate range of drug efflux pumps is not limited to antibiotics, but it also includes toxins, dyes, detergents, lipids, and molecules involved in quorum sensing; hence...

2008
Xiaowen R. Bina Christy L. Lavine Mark A. Miller James E. Bina

The ability of bacterial pathogens to infect and cause disease is dependent upon their ability to resist antimicrobial components produced by their host, such as bile acids, fatty acids and other detergent-like molecules, and products of the innate immune system (e.g. cationic antimicrobial peptides). Bacterial resistance to the antimicrobial effects of such compounds is often mediated by activ...

Journal: :The Journal of antimicrobial chemotherapy 2008
David Keeney Alexey Ruzin Fionnuala McAleese Ellen Murphy Patricia A Bradford

OBJECTIVES The purpose of this study was to characterize decreased susceptibility to tigecycline in clinical isolates of Escherichia coli obtained during Phase 3 clinical trials. METHODS Gene expression was analysed by transcriptional profile analysis and RT-PCR. Transposon mutagenesis with IS903kan was used for selection of transposon mutants. Transposon insertions were mapped by DNA sequenc...

Journal: :The Journal of veterinary medical science 2013
Toyotaka Sato Shin-ichi Yokota Torahiko Okubo Kanako Ishihara Hiroshi Ueno Yasukazu Muramatsu Nobuhiro Fujii Yutaka Tamura

Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. The AcrAB-TolC efflux pump contributes to resistance against fluoroquinolone and other antimicrobials. In this study, we investigated a high-level mechanism of fluoroquinolone resistance in E. coli that was isolated from human clinical samp...

Journal: :The Journal of antimicrobial chemotherapy 2009
Anna Fenosa Ester Fusté Lidia Ruiz Patricia Veiga-Crespo Teresa Vinuesa Victor Guallar Tomas G Villa Miguel Viñas

OBJECTIVES The Gram-negative human pathogen Klebsiella oxytoca is often resistant to several antibiotics such as fluoroquinolones, erythromycin, tetracycline, chloramphenicol and others. The aim of this study was to look at the mechanisms leading to this resistance and particularly the role of TolC and efflux mechanisms in determining resistance. METHODS Ciprofloxacin accumulation was measure...

2009
Jin-hui Hou Yong-hua Hu Min Zhang Li Sun

To date several classes of multidrug exporters have been identifi ed in prokaryotic cells, one of which is the resistance nodulation division (RND) family transporters (Poole and Srikumar, 2001). In this type of effl ux system, RND, an inner membrane proton-drug antiporter, forms a tripartite construct with a channel-forming outer membrane protein and an inner membrane protein of the MFP (membr...

Journal: :Journal of bacteriology 1997
D G Thanassi L W Cheng H Nikaido

Enteric bacteria such as Escherichia coli must tolerate high levels of bile salts, powerful detergents that disrupt biological membranes. The outer membrane barrier of gram-negative bacteria plays an important role in this resistance, but ultimately it can only retard the influx of bile salts. We therefore examined whether E. coli possessed an energy-dependent efflux mechanism for these compoun...

مقدمه و هدف: پمپ یا گردش خون برون پیکری به علت تحریک سیستمهای ایمنی انعقادی - کمپلمان و داشتن جریان خون بدون ضربان، تاثیرات مهمی بر ارگانهای بدن از جمله کبد دارد هدف این مطالعه بررسی اثرات پمپ بر روی تغییرات تستهای معمول کبدی پس از جراحی قلب باز است.مواد و روشها: 100 بیمار جراحی عروق کرونر و دریچه ای، تحت یک مطالعه کارآزمایی بالینی قرار گرفتند. متغیرهای زیر شامل، سن، جنس، نوع عمل، نوع پمپ، میزا...

2013
Sylvie Baucheron Simon Le Hello Benoît Doublet Etienne Giraud François-Xavier Weill Axel Cloeckaert

A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxa...

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