BACKGROUND Ventricular arrhythmias are life-threatening complications of heart failure and myocardial ischemia. Increased diastolic Ca2+ overload occurring in ischemia leads to afterdepolarizations and aftercontractions that are responsible for cellular electric instability. We inquired whether sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression could reduce ischemic ventricular ar...

Background—Heart failure often complicates myocardial infarction (MI), and sarcoplasmic/endoplasmic reticulum Ca -ATPase (SERCA2a) is underexpressed in the failing myocardium. We examined the effect of preexisting cardiac SERCA2a protein overexpression on rat survival and left ventricular (LV) remodeling after MI. Methods and Results—Baseline myocardial SERCA2a expression was 37% higher in tran...

BACKGROUND In myocardial infarction (MI), repolarization alternans is a potent arrhythmia substrate that has been linked to Ca2+ cycling proteins, such as sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), located in the sarcoplasmic reticulum. MI is also associated with oxidative stress and increased xanthine oxidase (XO) activity, an important source of reactive oxygen species (ROS) in the sarcopl...

AIMS Sarco(endo)plasmic reticulum Ca²(+)-ATPase 2a (SERCA2a) transports Ca²(+) by consuming ATP produced by mitochondrial respiratory chain enzymes. Messenger RNA (mRNA) for these enzymes is transcribed by mitochondrial transcription factors A (TFAM) and B2 (TFB2M). This study examined whether TFAM and TFB2M coordinately regulate the transcription of the Serca2 gene and mitochondrial genes. M...

Effects of SERCA Gene Transfer in Heart Failure To the Editor: We read with great interest the work by O’Donnell et al1 on the possible toxic effect of the sarcoplasmic reticulum Ca ATPase pump in neonatal cardiac myocytes. Because gene transfer of SERCA2a is being currently considered as a modality for the treatment of heart failure,2 the work by O’Donnell et al has the potential of raising co...

در میان شبکۀ معابر شهری، راه‌های اضطراری امدادرسانی حین زلزله، به‌ویژه مرحلۀ پاسخ به بحران، نقش مهمی ایفا می‌کنند. حفظ عملکرد این شبکه از معابر، ساعات اولیۀ پس اهمیت بسزایی دارد. محافظت و مقاوم‌سازی اجزای آسیب‌پذیر شبکه، به‌خصوص پل‌ها، پیش وقوع تأثیر شایان توجهی کاهش خسارات آسیب‌ها اغلب اوقات تمامی آسیب‌پذیر، به‌دلیل محدودیت بودجه، عملاً ناممکن است. ایجاب می‌کند که با شناسایی دقیق گزینه‌های ابتد...