نتایج جستجو برای: پلیمریزاسیون raft

تعداد نتایج: 7003  

2015
Xu Zheng Allison S. Li Huanyu Zheng Dongmei Zhao Dagang Guan Huawei Zou

In response to interleukin 6 (IL-6) stimulation, both CD45RO and CD45RB, but not CD45RA, translocate to lipid rafts. However, the significance of this distinct translocation and the downstream signals in CD45 isoforms-participated IL-6 signal are not well understood. Using sucrose fractionation, we found that phosphorylated signal transducer and activator of transcription (STAT)3 and STAT1 were...

Journal: :Annual review of biophysics and biomolecular structure 2003
Michael Edidin

Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, detergent solubili...

1998
Constantinos Dovrolis Parameswaran Ramanathan

For several real-time applications it is critical that the failure of a network component does not lead to unexpected termination or long disruption of service. In this paper, we propose a scheme called RAFT (Resource Aggregation for Fault Tolerance) that guarantees recovery in a timely and resource-eecient manner. RAFT is presented in the framework of the Reliable Backbone (RBone), a virtual n...

Journal: :The EMBO journal 2006
Satoshi Yamazaki Atsushi Iwama Shin-ichiro Takayanagi Yohei Morita Koji Eto Hideo Ema Hiromitsu Nakauchi

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known about inter- and intracellular signaling mechanisms underlying this unique property of HSCs. Here, we show that lipid raft clustering is a key event in the regulation of HSC dormancy. Freshly isolated HSCs from the BM niche lack lipid ra...

2017
Aabha I. Sharma Cheryl L. Olson David M. Engman

Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications. We isolated lipid rafts of the protozoan parasite Trypanosoma brucei and determined the protein composition of lipid rafts in the cell. This analysis revealed a striking enrichment of flagellar proteins and ...

خدادادی, سیروس, ریاضی, غلامحسین, نصیری خلیلی, محمدعلی, هاشمی شهرکی, فاطمه,

زمینه و هدف: در دهه های اخیر مطالعات بسیاری بر روی دینامیک پلیمریزاسیون دایمرهای توبولینی و نیز فاکتورهای موثر بر آن انجام شده است. بر اساس مطالعات صورت گرفته، لیپوپلی ساکارید (LPS) به صورت غیرمستقیم و از طریق مسیرهای آنزیمی، با هایپرفسفریلاسیون پروتین تاو، انفصال آن از میکروتوبول و در نهایت ناپایدارسازی شبکه های میکروتوبولی، در القاء بیماری های تحلیل برنده سیستم عصبی به خصوص آلزایمر نقش دارد. ...

2009
Mark Scanlon M. Tahar Kechadi

Providing the ability to any law enforcement officer to remotely transfer an image from any suspect computer directly to a forensic laboratory for analysis, can only help to greatly reduce the time wasted by forensic investigators in conducting on-site collection of computer equipment. RAFT (Remote Acquisition Forensic Tool) is a system designed to facilitate forensic investigators by remotely ...

2014
Xiao-Lei Han Yao-Kun Li Jing Ji Fan Luo

Values of site factors in numerical simulation can have profound effects on the calculation accuracy. In order to fully understand the performance of rigid-pile composite foundation in tall buildings, this article set up an overall FEA model of a 25-storey frame-tube structure by considering the interaction of superstructure, foundation and ground. Thereafter, a detailed parametric study was pe...

Journal: :Journal of immunology 2005
Min Zhang Miriana Moran June Round Teresa A Low Viresh P Patel Tamar Tomassian Joseph D Hernandez M Carrie Miceli

CD45 is dynamically repositioned within lipid rafts and the immune synapse during T cell activation, although the molecular consequences of CD45 repositioning remain unclear. In this study we examine the role of CD45 membrane compartmentalization in regulating murine T cell activation. We find that raft-localized CD45 antagonizes IL-2 production by opposing processive TCR signals, whereas raft-...

Journal: :The Journal of Cell Biology 2002
Philipp Niethammer Markus Delling Vladimir Sytnyk Alexander Dityatev Kiyoko Fukami Melitta Schachner

The neural cell adhesion molecule (NCAM) has been reported to stimulate neuritogenesis either via nonreceptor tyrosine kinases or fibroblast growth factor (FGF) receptor. Here we show that lipid raft association of NCAM is crucial for activation of the nonreceptor tyrosine kinase pathway and induction of neurite outgrowth. Transfection of hippocampal neurons of NCAM-deficient mice revealed that...

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