This paper discusses several dimensions involved in the design and implementation of future generations of Problem–Solving Environments (PSE). The paper surveys the main requirements posed both by end users and by system developers. The main issues on the development of future generation of PSEs are identified. A case study is then discussed which relates to an ongoing project in the author’s i...

The organization and quantity of myosin irrigation into myosin-free “ghost” fibers were compared between normal and PSE myosin. Considerable amounts of myosin were incorporated into the “ghost” fibers for both normal and PSE myosin. Elec t ron microscopic s tudy showed tha t the myosin f i laments were formed a l l over the thin filaments after the irrigation. However, there was almost no diffe...

P assive smoke exposure (PSE) is carcinogenic, linked to cardiovascular and respiratory diseases, increased risk for sudden infant death, and increased severity of asthma, and is generally harmful. 2 According to the behavioural ecological model (BEM), smoking and passive smoke exposure are behaviours influenced by interacting physiological, environmental, and cultural contingencies. Social mod...

BACKGROUND AND PURPOSE To describe the epidemiology and associations of poststroke epilepsy (PSE) because there is limited evidence to inform clinicians and guide future research. METHODS Data were collected from the population-based South London Stroke Register of first strokes in a multiethnic inner-city population with a maximum follow-up of 12 years. Self-completed forms and interviews no...

OBJECTIVE Pegylated-interferon/ribavirin (peg-IFN/RBV) therapy with a protease inhibitor is the standard therapy for genotype 1b chronic hepatitis C. Despite improving treatment outcomes, patients with thrombocytopenia are often difficult to treat because interferon commonly exacerbates thrombocytopenia. In this study, partial splenic embolization (PSE) was performed in patients with hypersplen...

Picture-story exercise (PSE) measures of implicit motives provide objective, stable, and valid scores. However, PSE scores are also characterized by substantial variability from one picture to the next, resulting in low internal consistency estimates. We argue that this variability is a critical source of the PSE’s validity because it reveals stable if-then contingencies between the situational...

Utilizing a screening method designed for the identification of genes involved with enhanced protein secretion in Saccharomyces cerevisiae we identified a gene, which we named PSE-1 (Protein Secretion Enhancer). Overexpression of PSE-1 in a multi-copy plasmid, as shown by Northern hybridization, gave a fourfold enhancement in total protein secretion. The repertoire of proteins that are found to...

The aim of this work was to study the sarcomeric organization of muscles with PSE-like zones and normal muscle (control), focusing on the SHG signal pattern of myosin (single or double band). Second harmonic generation microscopy has been applied on pork Semimembranosus samples fixed at 24 hours post mortem. Electronic microscopy was applied on the same samples to improve SHG images interpretat...

Chronic severe liver disease (i.e., cirrhosis) is a common complication of chronic alcohol abuse. Cirrhosis can cause brain dysfunction, most notably the disorder portal­systemic encephalopathy (PSE), which is characterized by cognitive and motor dysfunction and, eventually, by hepatic coma. Restoration of normal liver function—for example, through liver transplantation—can reverse some of the ...

Process systems engineering (PSE) has been an active research field for almost 50 years. Its major achievements includemethodologies and tools to support processmodeling, simulation and optimization (MSO). Mature, commercially available technologies have been penetrating all fields of chemical engineering in academia as well as in industrial practice. MSO technologies have become a commodity, t...