BACKGROUND Postmenopausal hormone (PMH) therapy represents a controversial colorectal cancer (CRC) preventive intervention. Because colorectal carcinogenesis is a heterogeneous process, we evaluated associations between PMH therapy and incident CRC in relation to KRAS mutation status in a population-based cohort of older women [Iowa Women's Health Study (IWHS)]. METHODS The IWHS enrolled 41,8...

Expression of calcitonin (CT) and its receptor (CTR) is elevated in advanced prostate cancer, and activated CT-CTR autocrine axis plays a pivotal role in tumorigenicity and metastatic potential of multiple prostate cancer cell lines. Recent studies suggest that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activ...

TOPIC Increasingly, students from various professional backgrounds are enrolling in Psychiatric Mental Health (PMH) Nursing graduate programs, especially at the post-master's level. Faculty must educate these students to provide increasingly complex care while socializing them as PMH advanced practitioners. PURPOSE To present how one online program is addressing these issues by reasserting th...

The Web 2.0 maximizes the Internet concept of encouraging its users to cooperate effectively for the offer of virtual services and content organization. Among the various potentialities of the Web 2.0, folksonomy appears as a result of the free assignment of tags to the Web’s resources by their users/ readers. Despite tags describe the Web’s resources, generally they are not integrated in the m...

Digital Libraries (DLs) have traditionally been positioned at the intersection of library science, computer science, and networked information systems. The different underlying philosophies of these three fields have had an unsettling influence on the development of DLs. While library science is fairly mature, networked information systems are constantly evolving to keep pace with Internet inno...

In 2013/14 the Deutsche Digitale Bibliothek (DDB) changed its data model from the CIDOC conceptual reference model to the Europeana Data Model (EDM). This decision was taken against the background of two major mandates the DDB has to fulfill: as a portal and as a platform the DDB is providing access to digital objects from German cultural heritage and research institutions. The DDB also aims to...

BACKGROUND Sex hormone concentrations are associated with breast cancer risk among women not using postmenopausal hormones (PMH); however, whether a relationship exists among PMH users is unknown. Therefore, we conducted a prospective, nested case-control study within the Nurses' Health Study (NHS) cohort to examine the association between plasma sex hormone concentrations and postmenopausal br...

The content description of various kinds of research data using metadata requires other than bibliographical data fields that are alone not sufficient for this purpose. To properly account for research data, other metadata fields are required, often specific to a given research data set. Consequently, metadata profiles adapted to different types of resources need to be created. These are define...

The International Development Research Centre (IDRC) has recently launched the OAI-PMH compliant IDRC Digital Library (IDL), a DSpace institutional repository. The digital library has been developed to enhance the dissemination of research outputs created as a result of Centre-funded research. The repository has a number of unique qualities. It is the public bibliographic database of a Canadian...

This paper introduces the write-once/read-many XMLtape/ARC storage approach for Digital Objects and their constituent datastreams. The approach combines two interconnected file-based storage mechanisms that are made accessible in a protocol-based manner. First, XMLbased representations of multiple Digital Objects are concatenated into a single file named an XMLtape. An XMLtape is a valid XML fi...