Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may contribute to PR activation by influencing PR dimer interaction in a Gag-Pol context. To determine if the enhancement of PR dimer interaction fac...

BACKGROUND Two randomised 12-week, double-blind, parallel-group, multicenter studies comparing oxycodone PR/naloxone PR and oxycodone PR alone on symptoms of opioid-induced bowel dysfunction in patients with moderate/severe non-malignant pain have been conducted. METHODS These studies were prospectively designed to be pooled and the primary outcome measure of the pooled data analysis was to d...

BACKGROUND The mechanism that initiates human parturition has been proposed to be 'functional progesterone withdrawal' whereby the 116 kDa B-isoform of the progesterone receptor (PR-B) switches in favour of the 94 kDa A-isoform (PR-A) in reproductive tissues. Recently, other PR isoforms, PR-S, PR-C and PR-M generated from the same gene have been identified and partially characterised. METHODS...

The two, nearly identical, isoforms of human progesterone receptors (PR), PR-B and -A, share activation functions (AF) 1 and 2, yet they possess markedly different transcriptional profiles, with PR-B being much stronger transactivators. Their differences map to a unique AF3 in the B-upstream segment (BUS), at the far N terminus of PR-B, which is missing in PR-A. Combined mutation of two LXXLL m...

AIMS Pulmonary regurgitation (PR) is an important determinant of outcome after tetralogy of Fallot (TOF) repair. The physiologic impact of PR on the right ventricle remains incompletely understood. We hypothesized that a volumetric expression of PR would be a better measure of ventricular preload and a more accurate reflection of degree of insufficiency. METHODS AND RESULTS Patients (n = 64) ...

  Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on...

ABSTRACT- Over the past 50 years, oil mulching has been a common technique for sand dune stabilization in the southwest of Iran (Khuzestan province). However, concerns over the release of heavy metals from oil mulching have led to the search for alternative mulches that are capable of stabilizing sand dunes without environmental hazards. This study investigates the feasibility of using sugarcan...

Pityriasis rosea is a short-lived rash that commences initially as a large so-called ‘herald’ patch followed by a rapidly evolving eruption on the trunk and extremities. Characteristic pattern of lesions follow the lines of cleavage in a ‘christmas tree’ distribution. PR is most frequently seen between first and third decade but a range of 3 month to 83 years were reported. The incidence doesn’...