نتایج جستجو برای: پارومومایسین paromomycin
تعداد نتایج: 485 فیلتر نتایج به سال:
Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsense and that this highly-allele-specific phenotypic suppression can be used to d...
A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetratin...
Nghiên cứu được thực hiện nhằm cải thiện độ nhạy của cảm biến sinh học nhận diện nhóm kháng ức chế sự tổng hợp protein trên nền giấy. Cảm dựa cường phát quang nanoluciferase (NanoLuc) giấy đông khô có chứa hệ thống phiên mã dịch trong điều kiện phòng thí nghiệm. Khi nhỏ nước lên giấy, NanoLuc và sáng khi kết với cơ chất Furimazine. Ngược lại, vi khuẩn, bị cản trở dẫn đến yếu. Cường ghi bằng máy...
Introduction Paromomycin1•`4) and aminosidineo are aminoglucoside antibiotics recently discovered. Identity of paromomycin and aminosidine has been reportedo. Knowledge of cross-resistance-relationships in respect to this antibiotic is very scanty. ARCAMONE et al. 5) stated that a neomycin-resistant strain of Staphylococcus aureus was resistant to paromomycin. The present study was carried out ...
The Zuotin-family J protein chaperone GlsA is essential for the asymmetric divisions that establish germ and somatic cell initials during embryogenesis in the green alga Volvox carteri, but it is not known on what cellular process GlsA acts to carry out this function. Most GlsA protein is nuclear, and GlsA possesses two SANT domains, suggesting that GlsA may function as a transcriptional regula...
UNLABELLED The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational synthesis focusing on 4' alkylations of the aminoglycoside paromomycin, with the goal to alleviate the most severe and disabling side effect of...
Translational leakiness (i.e., nonspecific suppression) of nonsense mutants of bacteriophage T4 is increased in cells of certain streptomycin-resistant strains previously grown in the presence of streptomycin. Concomitantly, ribosomes extracted from these streptomycin-grown cells possess a high level of misreading. Increased suppression ability as well as ribosomes that highly misread accumulat...
OBJECTIVE To compare the parasitological and clinical efficacy of four weeks versus two weeks of treatment with aminosidine (paromomycin) ointment in patients with cutaneous leishmaniasis caused by Leishmania major in the Islamic Republic of Iran. METHODS Double-blind, randomized trial of four weeks of aminosidine ointment (n = 108) vs two weeks of aminosidine ointment and two weeks of placeb...
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