BACKGROUND The K1 gene of human herpesvirus-8 (HHV-8; also known as Kaposi's sarcoma-associated herpesvirus) encodes a transmembrane signaling protein that elicits cellular activation events. To evaluate the potential role of K1 in HHV-8-associated pathogenesis, we produced transgenic mice expressing the HHV-8 K1 gene under the transcriptional control of the simian virus 40 promoter. METHODS ...

Separating the mixture of the K1(1270) and K1(1400) states, the B → K1(1270, 1400)νν transition form factors are calculated in the three-point QCD sum rules approach. The longitudinal, transverse and total decay widths as well as the asymmetry parameter, characterizing the polarization of the axial K1(1270, 1400) and the branching ratio for these decays are evaluated. PACS numbers: 11.55.Hx, 13...

We establish a new class of relations among the multiple zeta values ζ(k1, . . . , kl) = ∑ n1>···>nl≥1 1 n k1 1 · · ·n kl k , which we call the cyclic sum identities. These identities have an elementary proof, and imply the “sum theorem” for multiple zeta values. They also have a succinct statement in terms of “cyclic derivations” as introduced by Rota, Sagan and Stein. In addition, we discuss ...

Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp techniqu...

BACKGROUND AND PURPOSE Pentamidine is a drug used in treatment of protozoal infections. Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias associated with QTc prolongation and U-wave alterations. This proarrhythmic effect was linked to inhibition of hERG trafficking, but not to acute block of ion channels contributing to the action potential. Because the U-wav...

The semaphorin family contains a large number of secreted and transmembrane proteins, some of which are known to act as repulsive axon guidance cues during development or to be involved in immune function. We report here on the identification of semaphorin K1 (sema K1), the first semaphorin known to be associated with cell surfaces via a glycosylphosphatidylinositol linkage. Sema K1 is highly h...

We describe a high-performance liquid chromatographic procedure for the simultaneous measurement of vitamins K1 and E in human serum. Delipidated human serum (free of vitamins K1 and E) was used to make standard solutions of these vitamins, and cetyl naphthoate and alpha-tocopheryl acetate were the internal standards for vitamin K1 and vitamin E, respectively. A simple, novel separation method ...