نتایج جستجو برای: هموگلوبین a1
تعداد نتایج: 25563 فیلتر نتایج به سال:
زمینه و هدف: داروهای بر پایه پلاتین با اتصال به هموگلوبین سبب آزاد شدن گروه هِم از هموگلوبین شده، عملکرد هموگلوبین را مختل کرده و بدین ترتیب در بیمار تحت درمان ایجاد کم خونی می کند. هدف از تحقیق حاضر، بررسی اثرات جانبی اگزالی پالادیوم به عنوان یک داروی ضد سرطان جدید سنتزی، از طریق بر هم کنش با هموگلوبین و تخریب گروه هِم می باشد. روش بررسی: در این مطالعه تجربی، ساختار هموگلوبین انسانی در حضور و ع...
Monoclonal antibodies that bind to human leukocyte antigen (HLA) are useful tools for HLA-typing, tracking donor-recipient chimerisms after bone marrow transplants, and characterizing specific major histocompatibility complexes (MHC) on cell surfaces. Unfortunately, equivalent reagents are not available for rhesus macaques, which are commonly used animal as models in organ transplant and infect...
Let φ(x1, . . . , xh, y) = u1x1 + · · · + uhxh + vy be a linear form with nonzero integer coefficients u1, . . . , uh, v. Let A = (A1, . . . , Ah) be an h-tuple of finite sets of integers and let B be an infinite set of integers. Define the representation function associated to the form φ and the sets A and B as follows: R (φ) A,B (n) = card ({(a1, . . . , ah, b) ∈ A1 × · · · × Ah × B : φ(a1, ....
SP-A (surfactant protein A) is a membrane-associated SP that helps to maintain the lung in a sterile and non-inflamed state. Unlike SP-As from other mammalian species, human SP-A consists of two functional gene products: SP-A1 and SP-A2. In all the functions examined, recombinant human SP-A1 invariably exhibits lower biological activity than SP-A2. The objective of the present study was to inve...
Most individuals carry two wild-type M alleles of the SERPINA1 gene which encodes a1-antitrypsin. 95% of severe deficiency of a1-antitrypsin is associated with the Z allele (Glu342Lys; denoted PiZZ in the homozygote), and with the retention and polymerisation of a1-antitrypsin within hepatocytes [1]. These polymers are contained within periodic acid–Schiff-positive, diastase-resistant inclusion...
........................................................................................................77 Populärvetenskaplig Sammanfattning...........................................................78 References.....................................................................................................79
SGR 1900+14 had a brief episode of exceedingly rapid spindown immediately following its 1998 Aug. 27 superburst. On a timescale of hours, it increased its period by a part in 10. The corresponding Ṗ ∼ 10 is orders of magnitude higher than the typical quiescent rate of Ṗ ∼ 6×10.
We assume two loci under selection (A and B) and a third neutral locus C, each with two alleles denoted by A1 and A2, B1 and B2, and C1 and C2, respectively. Let the frequencies of alleles A1, A2, B1, B2, C1 and C3 be p, 1 p, q, 1 q, n and 1 n, respectively. We denote the recombination rate between locus i and j by rij and consider a continuous-time model, such that second-order terms of recomb...
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called betacasomorphins produced during digestion of raw or processed milk. It was shown that the betacasomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome. In this s...
Hyperoxic acute lung injury (HALI) is characterized by a cell death response with features of apoptosis and necrosis that is inhibited by IL-11 and other interventions. We hypothesized that Bfl-1/A1, an antiapoptotic Bcl-2 protein, is a critical regulator of HALI and a mediator of IL-11-induced cytoprotection. To test this, we characterized the expression of A1 and the oxygen susceptibility of ...
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