BACKGROUND Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory act...

Pentosan polysulfate (PPS) is a highly sulfated semisynthetic polysaccharide possessing a higher negative charge density and degree of sulfation than heparin. Like other glycosaminoglycans, the structural and chemical properties of PPS promote binding of the drug to the endothelium. Glycosaminoglycans, including heparin, inhibit complement activation independent of an action on the coagulation ...

Purpose: A growing number of treatment options and active compounds in treatments have led to better outcomes for patients with advanced or recurrent epithelial ovarian cancer. We examined the association between progression-free survival (PFS), post-progression survival (PPS) and overall survival (OS) in phase III trials of second- and third-line chemotherapy for advanced or recurrent epitheli...

OBJECTIVE To estimate costs and outcomes of conventional annual Papanicolaou (Pap) test screening compared with biennial Pap test plus speculoscopy (PPS) screening for cervical neoplasms. DESIGN A Markov model compared cost-effectiveness and outcomes of annual Pap tests with biennial PPS. The model includes direct costs of screening, diagnostic testing, and treatment for squamous intraepithei...

UNLABELLED We live in a dynamic environment, constantly confronted with approaching objects that we may either avoid or be forced to address. A multisensory and sensorimotor interface, the peripersonal space (PPS), mediates every physical interaction between our body and the environment. Behavioral investigations show high variability in the extension of PPS across individuals, but there is a l...

Five/six nephrectomy induces systemic and glomerular hypertension, glomerulosclerosis, proteinuria, and tubulointerstitial fibrosis. Polysulfate pentosan (PPS) decreases mesangial proliferation and extracellular matrix accumulation. The aim of this study was to determine whether PPS prevents glomerular hemodynamic changes and renal damage. Micropuncture studies were performed in three groups of...

BACKGROUND The debate over whether clinical psychologists should be granted the right to prescribe psychoactive medication has received considerable attention over the last 2 decades in the US, but there has been relatively little discussion of this controversial topic among Canadian mental health professionals, namely psychologists and psychiatrists. Proponents of prescription privileges (PPs)...

Nonstationary signals appear often in real-life applications and many of them can be modeled as polynomial phase signals (PPS). High-order ambiguity function (HAF) was rst introduced to estimate the parameters of a single component PPS. But due to its high nonlinearity, HAF has not been widely used for multi-component PPS which appear for example, in Doppler radar applications when multiple tar...

We present a small set of attachment heuristics for postnominal PPs occurring in full-text articles related to enzymes. A detailed analysis of the results suggests their utility for extraction of relations expressed by nominalizations (often with several attached PPs). The system achieves 82% accuracy on a manually annotated test corpus of over 3000 PPs from varied biomedical texts.

background public and private health sectors both play a crucial role in the health systems of low- and middleincome countries (lmics). the tuberculosis (tb) control strategy in india encourages the public sector to actively partner with private practitioners (pps) to improve the quality of front line service delivery. however, ensuring effective and sustainable involvement of pps constitutes a...