BACKGROUND AND PURPOSE Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability. MATERIALS AND METHODS Twenty-four patients with relapsing-remitting (RR, n = 13, age = 41.7 +/- 6.1, Exp...

BACKGROUND Fatigue is a common symptom of multiple sclerosis patients that may be present at all stages of the disease. The aim of this study was to determine presence of fatigue in multiple sclerosis patients during relapse and its relation to neurological disability and depression. SUBJECTS AND METHODS This cross-sectional study included 120 patients who were assessed during the acute relap...

OBJECTIVE To identify factors associated with culture-proven serious bacterial infection (SBI) and positive emergency department septic screening (EDSS) tests in children with bronchiolitis and to identify factors associated with the performance of EDSS. METHODS We reviewed an existing study database of patients with bronchiolitis. We defined a positive EDSS as urine with >/=10 WBC per high p...

PURPOSE The efficacy of statins in combination with interferon therapy in patients with multiple sclerosis (MS) is reviewed. METHODS A systematic literature search was conducted through September 2011 to identify randomized controlled trials that evaluated the effect of combination statin-interferon therapy compared with interferon therapy alone in patients with MS. Trials had to report at le...

High-dose cyclophosphamide (HDC) is a chemotherapy treatment designed to eradicate autoreative B- and T-cells responsible for lymphocyte-mediated autoimmune illness while sparing the pluripotent blood stem cell of any ill effects. Multiple sclerosis (MS) is the most common inflammatory and demyelinating immune-mediated disorder of the central nervous system in young adults. Patients with modera...

One possible explanation for this result is the size of the standard deviations of the measurements, which might be related to the wide range of Expanded Disability Status Scale (EDSS) scores permitted for patient inclusion. We are aware that a smaller range of EDSS scores would have selected a more homogeneous sample of subjects and probably would have reduced the size of the standard deviatio...

Background: Polysymptomatic or monosymptomatic patients of multiple sclerosis (MS) at the onset of the disease may influence the natural course of the disease. The purpose of this study was to determine the prognostic effect of the expanded disability status scale (EDSS) of patients with MS with polysymptomatic or monosymptomatic onset of the disease. Methods: From 2001 to 2011, 263 patients w...

Within the frame of E-Business and Internet literature, Web-based decision support systems have drawn the attention of researchers from a wide spectrum of disciplines. Web-Based Decision Support Systems can play a critical role, in ethical and trust decision situations. A variety of questions have been analyzed to determine which ethical and trust problems can be supported online. The results o...