The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

‎‎in cite{fr 1‎, ‎fr 2} using faithful complex representations of cyclically pinched and conjugacy pinched one-relator groups we proved that any limit group has a faithful representation in $psl(2,c)$‎. ‎further this representation can be effectively constructed using the jsj decomposition‎. ‎in this note we show that any hyperbolic cyclically pinched one-relator group with maximal amalgamated ...

Clive Oppenheimer ISTO, UMR 7327, CNRS/INSU, FR-45071 Orléans, France ISTO, UMR 7327, Université d’Orléans, FR-45071 Orléans, France ISTO, UMR 7327, BRGM, FR-45071 Orléans, France Institute for Advanced Studies, Le Studium, Orléans, France Department of Geography, University of Cambridge, Downing Place, Cambridge CB2 3EN, UK Marina Alletti ISTO, UMR 7327, CNRS/INSU, FR-45071 Orléans, France IST...

Plants exhibit morphological plasticity in response to changes the proportion of far-red radiation (FR). However, little is known about a sudden increase FR component. Cucumber seedlings were acclimatized without (FR-) for 1 - 5 d after germination, and then transferred containing (FR+) at levels similar those natural sunlight. Other FR- or FR+, which was maintained continuously. The damaged co...