Transgenic mice that allow mutant cells to be visualized in situ were used to study variation in tumors. These mice carry the G11 placental alkaline phosphatase (PLAP) transgene, a mutant allele rendered incapable of producing its enzyme product by a frameshift caused by insertion of a tract of G:C base pairs in a coding region. Spontaneous deletion of one G:C base pair from this tract restores...

Hybridization of Brassica napus L. (oilseed rape) and Raphanus raphanistrum L. (wild radish) has been demonstrated, and may be the first step towards introgression of transgenes in this wild relative. If wild radish were to display a new adaptive advantage by expressing the transgene, this could modify the ecological balance of species within the agro-ecosystem. To determine if transgenes remai...

Anaerobic syntrophic associations of fermentative bacteria and methanogenic archaea operate at the thermodynamic limits of life. The interspecies transfer of electrons from formate or hydrogen as a substrate for the methanogens is key. Contrary requirements of syntrophs and methanogens for growth-sustaining product and substrate concentrations keep the formate and hydrogen concentrations low an...

Fourteen thermotolerant and thermophilic bacterial isolates from a hot spring in Guanajuato State, Mexico, were tested for their ability to induce the corrosion of carbon steel in monocultures and, in selected cases, in mixed cultures and co-culture with a sulfate-reducing strain, SRB-M. Characterization by 16S rDNA showed that three of the thermophilic isolates (G9a, G9c, and G11) belong to th...

To establish the effect of low (11 mM) and high (55 mM) glucose concentrations (G11, G55) on Jurkat cells exposed to rotenone (ROT, a class 5 mitocan). We demonstrated that ROT induces apoptosis in Jurkat cells cultured in G11 by oxidative stress (OS) mechanism involving the generation of anion superoxide radical (O2(∙-), 68%)/hydrogen peroxide (H2O2, 54%), activation of NF-κB (32%), p53 (25%),...

In the chicken pineal gland, light stimuli trigger signaling pathways mediated by two different subtypes, Gt and G11. These G proteins may be activated by any of the three major pineal opsins, pinopsin, OPN4-1 and OPN4-2, but biochemical evidence for the coupling has been missing except for functional coupling between pinopsin and Gt. Here we investigated the relative expression levels and the ...

In these notes we compute the geodesic curvature on a surface in isothermal coordinates and use it to prove the local Gauß-Bonnet Theorem. These remarks are a continuation of my notes [T] whose notation we continue to employ. 1. Isothermal Coordinates of a Surface. The computations are facilitated by using a special coordinate system in which the metric and the resulting formulas take a particu...

We propose a tractable model of asset management in which benchmarking arises endogenously, and analyze its welfare consequences. Fund managers' portfolios are not contractible they incur private costs running them. Incentive contracts for fund managers create pecuniary externality through their effect on prices. Benchmarking inflates prices creates crowded trades. The crowding reduces the effe...