The present study explores the hypothesis that the new anti-epileptic drug levetiracetam (LEV) could interfere with the inositol 1,4,5-trisphosphate (IP(3))-dependent release of intracellular Ca(2+) initiated by G(q)-coupled receptor activation, a process that plays a role in triggering and maintaining seizures. We assessed the effect of LEV on the amplitude of [Ca(2+)](i) response to bradykini...

PURPOSE This study compared the efficacy and tolerability of intravenous (i.v.) phenobarbital (PHB) and i.v. levetiracetam (LEV) in children with status epilepticus (SE) or acute repetitive seizure (ARS). METHODS The medical records of children (age range, 1 month to 15 years) treated with i.v. PHB or LEV for SE or ARS at our single tertiary center were retrospectively reviewed. Seizure termi...

29 Levetiracetam (LEV) is one of the most commonly prescribed antiepileptic drugs, but its 30 mechanism of action is uncertain. Based upon prior information that LEV binds to the vesicular 31 protein Synaptic Vesicle Protein 2A (SV2A) and reduces presynaptic neurotransmitter release, 32 we wanted to more rigorously characterize its effect on transmitter release and explain the 33 requirement fo...

BACKGROUND Strokes are the leading cause of epileptic seizures in adults and account for 50% of seizures in those over the age of 65 years. The use of antiepileptic drugs to prevent recurrent poststroke seizures is recommended. METHODS One hundred and twenty-eight patients with poststroke seizures were randomly allocated to treatment with either levetiracetam (LEV) or sustained-release carbam...

PURPOSE To further elucidate possible immune-modulatory effects of valproate (VPA) or levetiracetam (LEV), we investigated their influence on apoptosis and cytotoxic function of CD8+ T lymphocytes in humans. METHODS In 15 healthy subjects (9 female (60%), 35.7±12.1 years), apoptosis and cytotoxic function of CD8+ T lymphocytes were measured using flow cytometry following in vitro exposure to ...

tolerated. Levetiracetam had a significant lower withdrawal rate than topiramate and oxcarbazepine with comparable efficacy. Gidal et al performed a pool analysis to determine the influence of levetiracetam in the serum concentrations of other antiepileptic drugs8. The study showed that LEV does not affect the concentration of carbamazepine, phenytoin, valproic acid, lamotrigine, gabapentin, ph...

Submitted for the MAR14 Meeting of The American Physical Society Synthetic gauge fields in quantum gases of dysprosium1 HUI ZHAI, Institute for Advanced Study, Tsinghua University, BENJAMIN LEV, Stanford University — To the toolbox of quantum gas-based many-body physics, highly magnetic atoms offer large, possibly non-perturbative, long-range dipolar interactions concomitant with extraordinaril...

The effect of proprioceptive feedback on the control of posture and locomotion was studied in the crayfish Procambarus clarkii (Girard). Sensory and motor nerves of an isolated crayfish thoracic nerve cord were connected to a computational neuromechanical model of the crayfish thorax and leg. Recorded levator (Lev) and depressor (Dep) nerve activity drove the model Lev and Dep muscles to move t...

Antiepileptic drugs (AEDs) are frequently used to treat seizures in glioma patients. AEDs may have an unrecognized impact in modulating O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumor cell resistance to alkylating agents. We report that levetiracetam (LEV) is the most potent MGMT inhibitor among several AEDs with diverse MGMT regulatory ...