Malignant mesothelioma has a poor prognosis for which there remains an urgent need for successful treatment approaches. Infection with the Edmonston vaccine strain (MV-Edm) derivative of measles virus results in lysis of cancer cells and has been tested in clinical trials for numerous tumor types including mesothelioma. Many factors play a role in MV-Edm tumor cell selectivity and cytopathic ac...

Within the minimal supersymmetric standard model (MSSM), the large tanβ regime can lead to important modifications in the pattern of CP-violating sources contributing to low energy electric dipole moments (EDMs). In particular, four-fermion CP-violating interactions induced by Higgs exchange should be accounted for alongside the constituent EDMs of quarks and electrons. To this end, we present ...

Attenuated Edmonston measles virus (MV-Edm) is not pathogenic in standard mice. We show here that MV-Edm inoculated via the natural respiratory route has a limited propagation in the lungs of mice with a targeted mutation inactivating the alpha/beta interferon receptor. A high dose of MV-Edm administered intracerebrally is lethal for about half of these mice. To study the consequences of the av...

An analysis of the neutron EDM and of the electron EDM in minimal N=1 supergravity unification with two CP violating phases is given. For the neutron the analysis includes the complete one loop gluino, chargino, and neutralino exchange diagrams for the electric dipole and the chromoelectric dipole operators, and also the contribution of the purely gluonic dimension six operator. It is shown tha...

In micro-electrical discharge machining (micro-EDM), dielectric plays a significant role during the machining process as different types of dielectrics have different chemical compositions, cooling rates and dielectric strengths. For this, dissimilar process responses are accounted when machining in EDM at micron level. The present paper investigates micro-EDM characteristics such as material r...

There has been an explosion of digital learning sensors. Some are in bespoke learning applications. But many more are in the digital tools people use in every aspect of their lives. This paper introduces a user-centred view of EDM for lifelong, life-wide learning. That includes formal education, but goes beyond it to the complex, multi-faceted and ill-defined learning in our broader lives. This...

Electrical discharge machining (EDM) is one of the most extensively used non-traditional machining processes having multiple performance characteristics, some of which are usually correlated. So, ideally, use of principal component analysis (PCA)-based approaches that take into account the possible correlations between the responses are suitable for optimization of EDM process. A recently repor...

BACKGROUND Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet. OBJECTIVE Intramuscular α-TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) α-TP in healthy foals. Serum and ...

In this paper, we use known bounds on the smallest eigenvalue of a symmetric matrix and Schoenberg’s Theorem to provide both necessary as well as sufficient trace inequalities that guarantee a matrix D is a Euclidean distance matrix, EDM. We also provide necessary and sufficient trace inequalities that guarantee a matrix D is an EDM generated by a regular figure.

whereas in electrical discharge machining (edm) the heat flux entering the workpiece is extremely high, the fourier heat conduction model may fails. this article reports on determination of temperature distribution in the workpiece due to edm using non-fourier heat conduction model. equations are solved by deriving the numerical solution. the temperature layers and profiles of sample calculatio...