A function is non-cooperative computable [NCC] if honest agents can compute it by reporting truthfully their private inputs, while unilateral deviations by the players are not beneficial: if a deviation from truth revelation can mislead other agents, then the deviator might end up with a wrong result. Previous work provided full characterization of the boolean functions which are non-cooperativ...

Hypertension is a leading cause of morbidity and mortality worldwide, and disordered sodium balance has long been implicated in its pathogenesis. Aldosterone is perhaps the key regulator of sodium balance and thus blood pressure. The sodium chloride cotransporter (NCC) in the distal convoluted tubule of the kidney is a major site of sodium reabsorption and plays a key role in blood pressure reg...

The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal conv...

The early Neoproterozoic sediments in the southern–southeastern (S-SE) North China Craton (NCC) are critical paleogeographic reconstruction. We present new detrital zircon U–Pb–Hf data of five sandstone samples from Sangwon Supergroup SE-NCC and Wufoshan Group S-NCC. integrate published U–Pb to appraise their provenance. dataset constrains maximum depositional age be ca. 1.0 Ga. similar provena...

THERE IS NO DOUBT ABOUT THE clinical importance of the thiazide-sensitive sodium chloride cotransporter (NCC). The NCC exists exclusively in the distal convoluted tubule and is responsible for 5–10% of NaCl reabsorption by the kidney. The efficacy of an inhibitor of the NCC, chlorothiazide, in lowering blood pressure was first demonstrated in 1958 (3), and thiazide diuretics continue to serve a...

The enteric nervous system (ENS) is mainly derived from vagal neural crest cells (NCC) that arise at the level of somites 1-7. To understand how the size and composition of the NCC progenitor pool affects ENS development, we reduced the number of NCC by ablating the neural tube adjacent to somites 3-6 to produce aganglionic gut. We then back-transplanted various somite lengths of quail neural t...