c-mpl is the receptor for the recently identified megakaryocyte growth and differentiation factor thrombopoietin. Thrombopoietin has been shown to be capable of raising platelet counts in animals and is about to enter clinical trials in humans. In anticipation of its likely use in the care of patients receiving cancer chemotherapy, we evaluated the expression of human c-mpl by reverse transcrip...

An L(d,1)-labeling of a graph G is an assignment of nonnegative integers to the vertices such that adjacent vertices receive labels that differ by at least d and those at a distance of two receive labels that differ by at least one, where d 1. Let d1 (G) denote the least such that G admits an L(d,1)-labeling using labels from {0, 1, . . . , }. We prove that (i) if d 1, k 2 and m0, . . . , mk−1 ...

The model of structure and structural transformation of the mesostructured carbon material CMK-1 was established by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) investigations. The investigations showed that the enantiomeric carbon subframeworks formed within the pores of the MCM48 mesoporous template used for the material synthesis displaced with respect to one ano...

During the late phase of megakaryopoiesis, megakaryocytes undergo polyploidization, which is characterized by DNA duplication without concomitant cell division. However, it remains unknown by which mechanisms this process occurs. AIM-1 and STK15 belong to the Aurora/increase-in-ploidy (Ipl)1 serine/threonine kinase family and play key roles in mitosis. In a human interleukin-3-dependent cell li...

Impaired megakaryocytopoiesis may be a contributing factor to thrombocytopenia associated with human immunodeficiency virus (HIV) infection. Because HIV isolates differ in their host range and pathogenicity, we investigated whether HIV strains with demonstrable cell tropism and increased cytopathicity for megakaryocytes could be derived from the blood of thrombocytopenic HIV-infected individual...