roglobulin, antimicrosome, or antiskeletal muscle autoantibodies whereas the generalised type showed a high titre and incidence of autoantibodies including AChR antibody.5 Seronegative patients or those with low AChR antibody may form a low responder subgroup of myasthenia gravis distinct from the high responders, who show a high titre of AChR antibody. Twelve patients (37 5%) were of the ocula...

Myasthenia gravis and myotonic dystrophy do not usually coexist; however, we present a rare case where both conditions coexisted. Herein, we describe a 34-year-old woman who presented with symptoms of myasthenia gravis with coexisting myotonic dystrophy. She complained of limb weakness, difficulty in chewing and swallowing, and ptosis. She also had myotonia. The patient’s brother also had simil...

1. Moran CA, Rosado-de-Christenson M, Suster S. Thymolipoma: Clinicopathologic review of 33 cases. Mod Pathol 1995;8:741-4. 2. Ozdemir N, Kara M, Dikmen E, Nadir A, Akal M, Yucemen N, et al. Predictors of clinical outcome following extended thymectomy in myasthenia gravis. Eur J Cardiothorac Surg 2003;23:233-7. 3. Rios ZA, Torres LJ, Roca CM, Martinez BE, Parrilla PP. Thymolipomas in associatio...

Sporadic reports have suggested central involvement in myasthenia gravis, a disorder in which there is an antibody-mediated loss of peripheral nicotinic acetylcholine receptors. Five patients with symptomatic myasthenia gravis performed an auditory vigilance test of ability to direct and sustain attention, presumed to reflect central cholinergic function. No deficits were found, either in compa...

Myasthenia gravis is a rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the myoneural junction. Psoriasis vulgaris is a chronic, recurring, and an inflammatory skin disease. Myasthenia gravis and psoriasis are both autoimmune diseases and correlated with specific human histocompatibility antigens. In this report, a 53-year-old woman who...

Congenital myasthenia gravis is caused by genetic mutations affecting neuromuscular transmission, characterized by muscle weakness usually starting in childhood. A two and a half years old male child presented with bilateral ptosis and hoarseness of voice. The symptoms progressed giving the clinical impression of congenital myasthenia gravis. A series of tests were done including Ice Pack Test,...

Rearrangement of T cell receptor (TCR) V8-J8 genes has been analyzed in 20 myasthenia gravis (MG) cases and 17 controls (blood donors) using the seminested polymerase chain reaction (PCR). Unlike the healthy subjects the majority of patients demonstrated a monoor oligoclonal type of rearrangement of TCR V51-6-J51 genes. It is suggested that T lymphocytes may undergo clonal expansion in myasthen...

Myasthenia gravis is an autoimmune disease that results from an antibody-mediated reaction and occurs with thymoma in 15% of patients. It is very rarely associated with autoimmune hepatitis. Four cases of myasthenia gravis with autoimmune hepatitis have been reported in the world. We recently experienced a case of 30-year-old man with myasthenia gravis associated with thymoma and autoimmune hep...

Bulbar weakness and fatigue resulting in dysphagia and dysarthria is common in myasthenia gravis. In chronic MG it is often assumed that these symptoms herald an exacerbation of the patient's disease and doses of cholinergic agents and immunomodulatory therapies may be increased, along with initiation of plasma exchange. A case is presented in which dysphagia was refractory to standard MG thera...

A case of myasthenia gravis in a 15 years old girl is pre·sented. The disease was present for 5 years before thymectomy was performed. Indications for thymectomy, preoperative pre­paration, anesthetic and surgical management is -discussed.