The application of ionizing radiations in different fields requires the use of equipment capable of detecting their presence or quantifying them. Detectors of the most different shapes, composition and characteristics are required to cover the full range of application of ionizing radiations. At present, thermoluminescent detectors (TLD) are the most widely employed for individual gamma monitor...

A 65 year old male with metastatic colorectal cancer (mCRC) in the liver was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy. 90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion dosimetry was highly predictive of eventual response in ...

Radioembolization (RE) with glass microspheres (MS) loaded Yttrium-90 (90Y) has been used to treat tumors in the liver some reported success. However, assessing absorbed doses (AD) planning tumor volume (PTV) and normal (NLV) is a key problem address RE. In clinical practice, computation of 90Y activity be administered follows manufacturer’s recommendations, which do not consider specific chara...

INTRODUCTION Yttrium 90-ibritumomab tiuxetan (90Y-IT) radioimmunotherapy has proved to be effective in relapsed follicular lymphoma (FL). We conducted a clinical trial in which 90Y-IT followed by maintenance rituximab (MR) was evaluated as initial therapy for high-tumor-burden FL. METHODS Eligible patients had histologically confirmed FL and met the GELF (Groupe d'Etude des Lymphomes Follicul...

(1) Background: New generation of PET-CT scanners allows performing volumetric dosimetry based on 90Y-activity distribution. The aim this study was to perform an up-to-date evaluation the optimal 90Y-PET-CT reconstruction parameters for a Siemens Biograph mCT scanner. (2) Methods: A cylindrical uniform phantom (P1), IEC NEMA Body-phantom (P2) and Torso-phantom (P3) filled with 90Y were acquired...

The increasing incidence of non-Hodgkin's lymphoma (NHL), coupled with the lack of optimal treatment options, has prompted the development of novel treatments. Of these, radioimmunotherapy is one of the most promising. Two of the radiolabeled monoclonal antibody therapies being studied in the treatment of NHL are yttrium 90 (90Y) ibritumomab tiuxetan and iodine 131 (131I) tositumomab. The radio...

Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill target cells, including cancer cells. Aqueous 32P[PO4] is a pure beta-emitter that has been used for several decades to treat non-malignant human myeloproliferative diseases. 32P[PO4] was directly compared to a more powerful pure beta-emitter, the clinically important 90Y isotope. In vitro, 32P[PO4] wa...

Therapeutic trials were performed on the HepG2 human hepatoblastoma implanted s.c. in the athymic nude mouse. Animals were treated with polyclonal and monoclonal antiferritin and control antibodies labeled with either iodine-131 (131I) or yttrium-90 (90Y). Administration of 400 muCi of 131I-labeled polyclonal antiferritin or 300 muCi of 90Y-labeled polyclonal antiferritin significantly increase...

a 65 year old male with metastatic colorectal cancer (mcrc) in the liver was referred for selective internal radionuclide therapy (sirt) following a history of extensive systemic chemotherapy. 90y pet imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. lesion dosimetry was highly predictive of eventual response in ...

In order to study the role of natural killer (NK) cells during the early period of Leishmania infection, BALB/c mice were selectively and permanently depleted of NK cells by injection with 90Sr and subsequently infected with Leishmania (Leishmania) amazonensis (HSJD-1 strain). 90Sr is known to selectively deplete NK cells, leaving an intact T- and B-cell compartment and preserving the ability t...