The Pim protein kinases (provirus insertion site of Moloney murine leukemia virus) have been identified as important actors involved in tumor cell survival, proliferation, migration and invasion. Therefore, inhibition of Pim activity by low molecular weight compounds is under investigation as a part of anticancer therapeutic strategies. We have synthesized a series of pyrrolo[2,3-a]carbazole de...

Mesenchymal-epithelial transition (MET) blockade offers a new targeted therapy particularly in those cancers with MET amplification. However, the efficacy and the duration of the response to MET inhibitors are limited by the emergence of drug resistance. Here, we report that resistance to small-molecule inhibitors of MET can arise from increased expression of the prosurvival Pim protein kinases...

Manaus Industrial Pole (PIM) is located in Manaus Amazonas State, Brazil and it is an important complex in Latin America. It covers more than 400 companies with high indexes of technological innovation and productivity. PIM goals the sustainable use of the economic potentialities, creating new jobs and a better income distribution. The PIM is interconnected to the country’s, Southern and Southe...

While Processing-In-Memory (PIM) has been widely researched for the last two decades, it was never truly adopted by the industry and remains mostly within the academic research realm. This is mainly because (1) inmemory compute engines were too slow, and (2) a realworld application that could really benefit from PIM was never identified. In recent years, the first argument became untenable, but...

The PIM family of serine/threonine kinases have become an attractive target for anti-cancer drug development, particularly for certain hematological malignancies. Here, we describe the discovery of a series of inhibitors of the PIM kinase family using a high throughput screening strategy. Through a combination of molecular modeling and optimization studies, the intrinsic potencies and molecular...

Purpose – The column explores the potential of personal information management (PIM) and reference management. This contribution focuses on collaboration: the issues that need to be addressed in planning, the human component in collaborative information seeking, and issues for research by librarians. Design/methodology/approach – The column is written against the background of research from inf...

Potent survival effects have been ascribed to the serine/threonine kinase proto-oncogene PIM-2. Elevated levels of PIM-2 are associated with various malignancies. In human cells, a single Pim-2 transcript gives rise mainly to two protein isoforms (34, 41 kDa) that share an identical catalytic site but differ at their N-terminus, due to in-frame alternative translation initiation sites. In this ...

Abstract This research reports on qualitative interviews with 31 participants who are Irish parents, identify as lesbian, gay, bisexual, queer (LGBQ), and expressed difficulty in the process of obtaining birth certificates for their children. Our aim was to use personal information management (PIM) digital archiving (PDA) a lens explore invisible work that government requires sexual minority pa...

Demand for data-intensive workloads and confidential computing are the prominent research directions shaping future of cloud computing. Computer architectures evolving to accommodate large data better. Protecting computation sensitive is also an imperative yet challenging objective; processor-supported secure enclaves serve as key element in cloud. However, side-channel attacks threatening thei...

Objective: This study aims to examine potentially inappropriate medication (PIM) prevalence and factors that affect the use of PIMs in a military treatment facility. Method: Admission and discharge medication lists of 60 patients aged ≥65 years were retrospectively reviewed by a clinical pharmacist and a member of the study team for the presence of PIM using the 2012 Beers Criteria. Patients in...