نتایج جستجو برای: مسیر ras

تعداد نتایج: 54191  

2015
Ulrike May Stuart Prince Maria Vähätupa Anni M. Laitinen Katriina Nieminen Hannele Uusitalo-Järvinen Tero A. H. Järvinen

The R-ras gene encodes a small GTPase that is a member of the Ras family. Despite close sequence similarities, R-Ras is functionally distinct from the prototypic Ras proteins; no transformative activity and no activating mutations of R-Ras in human malignancies have been reported for it. R-Ras activity appears inhibitory towards tumour proliferation and invasion, and to promote cellular quiesce...

2012
Samantha Messina Luigi Frati Antonio Porcellini

Addition of hydrogen peroxide to cultured astrocytes induced a rapid and transient increase in the expression of Ha-Ras and Ki-Ras. Pull-down experiments with the GTP-Ras-binding domain of Raf-1 showed that oxidative stress substantially increased the activation of Ha-Ras, whereas a putative farnesylated activated form of Ki-Ras was only slightly increased. The increase in both Ha-Ras and Ki-Ra...

Journal: :نشریه پرستاری ایران 0
شهین دخت اشجعی ashjai sh.

extract  although there are new ways to portray the brain, colored and computerized encephalography but coma is still unknown and such as death remain beyond comprehension and knowing. is not it ?   perhaps because of this, despite knowing that some part of the brain is not yet fully understood all its parts. but knowing the components that working to each other is key for discovering a lot of ...

2012
Katy A. Wong Angela Russo Xuerong Wang Yun-Ju Chen Arnon Lavie John P. O'Bryan

The intersectin 1 (ITSN1) scaffold stimulates Ras activation on endocytic vesicles without activating classic Ras effectors. The identification of Class II phosphatidylinositol 3-kinase beta, PI3KC2β, as an ITSN1 target on vesicles and the presence of a Ras binding domain (RBD) in PI3KC2β suggests a role for Ras in PI3KC2β activation. Here, we demonstrate that nucleotide-free Ras negatively reg...

Journal: :Journal of cell science 2001
I A Prior J F Hancock

The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms within the plasma membrane is also critical for their function. H-...

2018
Sun-Ju Yi Seong Yun Hwang Myung-Ju Oh Yang-Hoon Kim Hojin Ryu Sung-Keun Rhee Byung H Jhun Kyunghwan Kim

Signal transduction pathways regulate the gene expression by altering chromatin dynamics in response to mitogens. Ras proteins are key regulators linking extracellular stimuli to a diverse range of biological responses associated with gene regulation. In mammals, the three ras genes encode four Ras protein isoforms: H-Ras, K-Ras4A, K-Ras4B, and N-Ras. Although emerging evidence suggests that Ra...

2013
Veronica Aran Ian A. Prior

Ras isoforms are membrane bound proteins that differentially localize to the plasma membrane and subcellular compartments within the cell. Whilst the cell surface is the main site for Ras activity the extent to which intracellular pools contribute to Ras function is debated. We have generated Ras chimeras targeting Ras to the ER, Golgi, mitochondria and endosomes to compare the capacity of each...

Journal: :journal of craniomaxillofacial research 0
arghavan tonkaboni department of oral medicine, school of dentistry, tehran university of medical sciences, international campus, tehran, iran. shamsoulmolouk najafi department of oral medicine, school of dentistry, tehran university of medical sciences, international campus, tehran, iran. saba mehrpour school of dentistry, tehran university of medical sciences, international campus, tehran, iran. mohammad javad kharazi fard3 dental research center, dentistry research institute, tehran university of medical sciences, tehran, iran.

introduction : recurrent aphthous stomatitis (ras) is an oral lesion in the form of round or oval, single or multiple painful inflammatory ulcers in the non-keratinized mucosa. the etiology of ras has not yet to be clearly identified; however, inflammatory process mediated by the action of free radicals and oxidative stress is a possible mechanism. this study aimed to assess the efficacy of pro...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علوم کشاورزی و منابع طبیعی ساری - دانشکده کشاورزی 1393

آبراهه های طبیعی و رودخانه ها برای ایجاد یک تعادل نسبی همواره در حال تغییر و دگرگونی هستند. تغییر در مورفولوژی رودخانه به دلیل تغییر در میزان ظرفیت انتقال رسوبات می باشد. از آنجایی که رودخانه یک سیستم پویاست، همواره ظرفیت انتقال رسوب آن به دلیل عوامل مختلف در حال افزایش و کاهش است که این امر، فرسایش و رسوب گذاری در مسیر رودخانه را به همراه دارد. شناخت پدیده ها و آثار ناشی از تغییرات آن بر شرایط...

Journal: :Genes & development 1997
L Johnson D Greenbaum K Cichowski K Mercer E Murphy E Schmitt R T Bronson H Umanoff W Edelmann R Kucherlapati T Jacks

Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in approximately 30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development. To characterize the normal role of K-ras in growth and development, we have mutated it by gene targeting in the mouse. On an inbred genetic background, embryos hom...

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