The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response; and complex regulation of DAF-16/FOXO by SIR-2.1/SIRT1 is central to appropriate biological outcomes. Caenorhabditis elegans Host Cell Factor 1 (HCF-1) is a longevity determinant previously shown to act as a co-repressor of DAF...

BACKGROUND We conducted a large national cohort study to examine the risk of cancer among men and women with genital warts (GW). METHODS By use of the Danish National Patient Register, we identified 16,155 men and 32,933 women who received a diagnosis of GW during 1978-2008. Standardized incidence ratios (SIRs) were computed as estimates of the relative risk of specific cancers or sites. RE...

Gac Sanit. 2005;19(5):417-9 a Sir Autin Bradford Hill que ha seguido dando frutos hasta hace bien poco. El abandono del tabaquismo por la mayoría de los médicos ingleses, entre los que se contaba él mismo, fue el primer paso de una contribución que ha evitado millones de muertes prematuras. Exploró la relación del tabaco con el cáncer de vejiga y otros cánceres y con las enfermedades cardiovasc...

There are times when something is simply so familiar that we can no longer see it at all. It can be a story, or a concept, or even a flesh-and-blood person. Familiarity breeds not only contempt, but a kind of invisibility as well. For too many of us, such is the case with Sir William Osler. In his time (1849–1919), many considered him to be one of the greatest practitioners, teachers, and write...

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The cause of the Association for Mental Welfare, no less than the scientific aspect of psychiatry, has suffered a great loss by the death of Sir Frederick Mott. This is no place to deal in detail with the purely scientific side of his activities, but some knowledge of their general tendency is required in order to assess the great influence that he exercised on our conceptions of the treatment ...

We present a sector-based resource allocation scheme for broadband fixed wireless networks. For SIR requirements of about 12 to 14 dB, the scheme can deliver an effective reuse factor of one, while permitting a given spectrum to be re-used in every sector of every cell. The scheme also offers flexible sector planning, easy capacity growth, and addresses irregular cell layout and non-uniform tra...