نتایج جستجو برای: مدل hbv light
تعداد نتایج: 530883 فیلتر نتایج به سال:
The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication. Here, we described a novel gRNA-microRNA (miRNA)-gRNA ternary cassette driven by a single U6 promoter. With an anti-HBV pri-miR31 mimic integrated between two HBV-specific gRNAs, both gRNAs could be separated from the long transcript of gRNA-miR-HBV-gRNA ternary cassette thro...
BACKGROUND Hepatitis B virus (HBV) genotypes can influence treatment outcome in HBV-monoinfected and human immunodeficiency virus (HIV)/HBV-coinfected patients. Tenofovir disoproxil fumarate (TDF) plays a pivotal role in antiretroviral therapy (ART) of HIV/HBV-coinfected patients. The influence of HBV genotypes on the response to antiviral drugs, particularly TDF, is poorly understood. METHOD...
BACKGROUND Occult infection with hepatitis B virus (HBV) is a type of chronic HBV infection that is characterized by the absence of a detectable hepatitis B surface antigen in the blood and by very low levels of HBV DNA in the blood and liver. The mechanisms leading to occult HBV infection remain poorly understood but include possible genetic mutations and deletions. Recently, it has been shown...
Hepatitis B virus (HBV) is an important pathogen that chronically infects more men than women. To understand the molecular mechanism of this gender disparity, we analyzed HBV replication in transgenic mice that carried the HBV genome with or without the ability to express the HBV X protein (HBx). We found that gender had no effect on HBV surface antigen (HBsAg), DNA, and RNA levels in mice befo...
BACKGROUND Hepatitis B virus (HBV) is a hepatotropic virus that can infect extrahepatic tissue. Whether hematopoietic stem cells (HSCs) can be infected by HBV and serve as a potential virus reservoir is still unknown. In this study, the susceptibility of CD34+ HSCs to HBV was investigated. MATERIAL AND METHODS Cord blood-derived CD34+ HSCs were exposed to HBV in vitro, and immunocytochemistry, ...
Given the shared risk factors for transmission, coinfection with hepatitis B virus (HBV) and HIV is common. HIV infection increases the risk of chronic HBV infection and hastens the progression of liver disease in patients with chronic HBV infection. The treatment of chronic HBV infection needs to be carefully coordinated with HIV management in HBV-HIV coinfected patients. The main goals of tre...
BACKGROUND & AIMS AIM2 plays an important role in innate immunity, but its role in regulating the immune response to hepatitis B virus (HBV) is unknown. We hypothesized that AIM2 expression is positively correlated with HBV-mediated inflammation in patients with HBV-associated glomerulonephritis (HBV-GN), potentiating inflammation and leading to renal damage. We therefore analyzed the expressio...
سابقه و هدف: فعال شدن مجدد ویروس هپاتیت B (HBV)، یک عامل خطر عمده برای ایجاد اختلال عملکرد کبد، هپاتیت حاد و مزمن، سیروز و سرطان کبد بعد از پیوند کلیه (KTP) می باشد. این مقاله بعضی از مقالات چاپ شده در باره پیشگیری از فعال شدن مجدد HBVدر گیرنگان پیوند کلیه را خلاصه نموده است. مواد و روشها: برای جمع آوری اطلاعات موجود در باره این موضوع، مقالات چاپ شده زیادی که به زبان انگلیسی و به صورت مقاله ...
Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...
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