The role of radiotherapy (RT) in immunotherapy-based (IO) combinatory approaches to advanced NSCLC is still uncertain due its dual immune -suppressive and -stimulatory effect. We performed a longitudinal peripheral blood (PB) analysis determine whether RT, by affecting cell phenotypes dynamics, impacts on clinical outcome IO-treated patients. PB samples were prospectively collected at baseline ...

The critical maturation time of central otolith neurons in processing spatial orientations was examined in Sprague-Dawley rats. With the use of immuno-hybridization histochemical methods, we observed c-fos expression in vestibular nuclear neurons responding to transverse movement on the horizontal plane as early as P7 and those to antero-posterior stimulation as early as P9. In the inferior oli...

This paper presents the next generation AC IO Loopback design for two Intel processor architectures. Both designs detect I/O defects with 20 ps resolution and 50 ps jitter for up to 800 MHz bus speed. Even though the implementations differ in some aspects to accommodate two different bus architectures, the same prudent considerations for high speed operation, minimum test inaccuracy, and low im...

The problem of redistributing IO from bondpads on the periphery of an IC to an array of solder bumps occurs frequently in MCM layout. We show that the commonly held belief that providing enough escapes at the perimeter of the array is not suucient to guarantee routability of the design. We analyze the Even Wiring Distribution (EWD) routing heuristic and show that it produces designs whose criti...

در این مقاله یک مدل ریاضی برای مسئله سیستم تولیدی همکارانه ساخت بر اساس سفارش با رعایت انصاف تخصیص بار‌های تولید طراحی شده است. اهداف اصلی مدل، کمینه‌سازی هزینه‌‌های کل و حداکثر استفاده از منابع به‌منظور عادلانه شرایط عدم­قطعیت کنترل پارامتر‌های غیرقطعی روش برنامه‌ریزی فازی ‌شده نتایج نشان می‌دهد افزایش نرخ عدم‌قطعیت، می­یابد. ازآنجاکه ظرفیت کارخانه‌ها ثابت است، مقدار تقاضا، هر کارخانه نیز می­ی...

In this work, Dehydroleucodine (DhL) was evaluated as a chemical activator of bovine oocytes and somatic cell nuclear transfer (SCNT) reconstituted embryos. Oocytes were activated with 5 microM Ionomycin (Io) and exposed for 3 h to 1 or 5 microM DhL alone (Io-Dhl1 or Io-DhL5) or combined with Cytochalasin B (Io-DhL1/CB; Io-DhL5/CB). Control groups were Io (Io), Io followed by 1.9 mM 6-Dimethyla...