نتایج جستجو برای: مدل آسیب gtn

تعداد نتایج: 140472  

Journal: :Rheumatology 2002
M E Anderson T L Moore S Hollis M I V Jayson T A King A L Herrick

OBJECTIVE To investigate digital microvascular responses to topical glyceryl trinitrate (GTN) in patients with primary Raynaud's phenomenon (PRP), limited cutaneous systemic sclerosis (LCSSc) and healthy control subjects, using laser Doppler imaging. METHODS Ten patients with PRP, 13 with LCSSc and 10 control subjects were studied. Baseline skin microvascular blood flow of the dorsum of the i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
David R Janero Nathan S Bryan Fumito Saijo Vijay Dhawan David J Schwalb Michael C Warren Martin Feelisch

Nitric oxide (NO)-derived products may modify tissue constituents, forming S- and N-nitroso adducts and metal nitrosyls implicated in NO signaling. Nitrovasodilator drugs have been in widespread use for more than a century, yet their biotransformation pathways to NO and their effects as NO donors across tissues remain ill defined. By using a metabonomics approach (termed "NObonomics") for detai...

Journal: :Circulation 1992
T Münzel A Mülsch J Holtz H Just D G Harrison E Bassenge

BACKGROUND L-Methionine potentiates systemic hemodynamic effects of intravenous glyceryl trinitrate (GTN) in tolerant and nontolerant patients to a similar extent as N-acetylcysteine (NAC). This potentiation of GTN action by L-methionine has been attributed to enhanced intracellular formation of nitrosothiols, known to be potent stimulators of soluble guanylyl cyclase. This study was performed ...

Journal: :CoRR 2015
Peng Sun James K. Min Guanglei Xiong

Recently, a successful pose estimation algorithm, called Cascade Pose Regression (CPR), was proposed in the literature. Trained over Pose Index Feature, CPR is a regressor ensemble that is similar to Boosting. In this paper we show how CPR can be represented as a Neural Network. Specifically, we adopt a Graph Transformer Network (GTN) representation and accordingly train CPR with Back Propagati...

2014
YEBIN LU JUANJUAN HU WEIJIA SUN XIAOHUI DUAN XIONG CHEN

The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm3, the mice in the GTN group were treated with GTN tr...

2010
Bin Chen Tao Fan Chun-hui Wang

BACKGROUND Glyceryl trinitrate (GTN) has been shown to be able to relax the sphincter of Oddi (SO) both in animals and humans. Theoretically, the use of these compounds during and after endoscopic retrograde cholangiopancreatgraphy (ERCP) could relax the biliary and pancreatic sphincters, facilitating cannulation of common bile duct (CBD) during the procedure, or minimizing potential pancreatic...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
J D Ratz J J McGuire D J Anderson B M Bennett

The flavoprotein inhibitor, diphenyleneiodonium (DPI), inhibits the action of glyceryl trinitrate (GTN) and the D-enantiomer of isoidide dinitrate (IIDN), but not the L-enantiomer (L-IIDN), in isolated rat aorta via inhibition of the bioactivation of these prodrugs. Paradoxically, a vascular NAD(P)H oxidase, which also is inhibited by DPI, has been proposed to generate superoxide that quenches ...

2011
Reda Abd Elhady Hemida Eman Toson Hend Shalaby Ehsan Refaie Doaa Sharaf Eldin

Introduction: Gestational trophoblastic neoplasia (GTN), is recognized as the most curable gynaecologic malignancy. However, many cases are resistant to first line chemotherapy. Objective: The aim of the study is to report our 5 years experience in the management of GTN cases with special stress on the chemo-resistant cases. Methods: The study was performed through reviewing the records of 51 p...

Background: Gestational Trophoblastic Neoplasia (GTN) is the malignant form of gestational trophoblastic disease that has different capabilities in metastasis and invasion stance. Therefore, the aim of this study was to identify an appropriate and applicable longitudinal marker, using the serum human chorionic gonadotropin (hCG) levels during 21 days after mole evacuation for predicting the ges...

2016
Malihe Hasanzadeh Ftemeh Vahid Roodsari Shahnaz Ahmadi Masoumeh Gavedan Mehr Tabari Azadeh

BACKGROUND Gestational trophoblastic neoplasia (GTN) is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblast...

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