The region surrounding the dopa decarboxylase gene of Drosophila contains a cluster of functionally related genes, many of which affect cuticle development and/or catecholamine metabolism. In this report we describe the molecular mapping and sequencing of a full-length cDNA copy of a transcript that maps to the alpha-methyldopa hypersensitive region. Developmental RNA blots show stage-specific ...

A 2-week-old infant with normal intracardiac anatomy presented to the emergency department in a hypertensive crisis with acute cardiac failure. Despite extensive evaluation, no underlying disease was found. The patient's hypertension and cardiac dysfunction resolved after 1 week of supportive care in the PICU, and she was discharged within 2 weeks of presentation. The patient's history revealed...

The effects of methyldopa and alprenolol were compared in I5 patients with previously untreated essential hypertension. The patients were randonly allocated to start treatment with one of the drugs. All blood pressures and side effects were registered blindly as regards type of treatment by the same observer. The study was not blind as regards the patients as non-matching tablets were used. Alp...

Case Presentation A 30-year-old woman was admitted to the hospital because of hypertension and hypokalemia. She had had a normal blood pressure measurement 5 years prior to admission and had been in good health until approximately 1 year before admission when a severe frontal headache and cramping in her hands and feet developed. She was seen in an emergency room and was noted to be hypertensiv...

The oral absorption of amino acids, small peptides and their analogs has been studied in rats using single pass intestinal perfusion, The experimental data was analyzed using a modified boundary layer method permitting the calculation of intrinsic membrane absorption parameters. Cefatrizine, L-Dopa, cu-methyldopa, and L-PHE demonstrated concentration dependent absorption. Furthermore, the absor...

At age 7.5 years the supine blood pressures of 216 children born to women who had been hypertensive during pregnancy were recorded. No associations were found between the blood pressures of the children and their mothers. The blood pressures of children whose mothers received methyldopa during pregnancy did not differ from those of children whose mothers had no specific treatment. Four boys who...

background: alpha methyldopa (amd) is a well-known treatment for the pregnancy induced hypertension and commonly used in several countries. indeed the possible effect of amd on the behavioral activities of offspring, whom are exposed during fetus period, has not been studied. the present study evaluated the possible effect of maternal administration of amd on the rat offspring memory in the gro...