Shi, Hong, Hui-Zhen Wang, and Zhiguo Wang. Extracellular Ba21 blocks the cardiac transient outward K1 current. Am. J. Physiol. Heart Circ. Physiol. 278: H295–H299, 2000.—Ba21 is widely used as a tool in patch-clamp studies because of its ability to block a variety of K1 channels and to pass Ca21 channels. Its potential ability to block the cardiac transient outward K1 current (Ito) has not been...

OLUGBENGA A. ADEBANJO,1 GOPA BISWAS,2 BALJIT S. MOONGA,1 HINDUPUR K. ANANDATHEERTHAVARADA,2 LI SUN,1 PETER J. R. BEVIS,1 BALI R. SODAM,1 F. ANTHONY LAI,3 NARAYAN G. AVADHANI,2 AND MONE ZAIDI1 1Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, and Bronx Veterans Affairs Geriatric Research Education and Clinical Center, New York 10029; 2School of Veterinary Medicine, Unive...

Ali, Shujath M., Victoria Y. Wong, Kristine Kikly, Todd A. Fredrickson, Paul M. Keller, Walter E. DeWolf, Jr., Dennis Lee, and David P. Brooks. Apoptosis in polycystic kidney disease: involvement of caspases. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R763– R769, 2000.—Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss o...

Matsumura, Kiyoshi, Isao Abe, Takuya Tsuchihashi, and Masatoshi Fujishima. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. Am J Physiol Regulatory Integrative Comp Physiol 278: R1314–R1320, 2000.—We determined the cardiovascular and neurohormonal responses to intracerebroventricular injection of leptin in conscious rabbits. Intracerebroventricular i...

Burckhardt, Gerhard, and Natascha A. Wolff. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 278: F853–F866, 2000.—Here we review the structural and functional properties of organic anion transporters (OAT1, OAT2, OAT3) and organic cation transporters (OCTN1, OCTN2, OCT1, OCT2, OCT3), some of which are involved in renal proximal tubular organic anion and cati...

Peri, Irena, Hanna Mamrud-Brains, Sergey Rodin, Valery Krizhanovsky, Yechiel Shai, Shlomo Nir, and Michael Naim. Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Am. J. Physiol. Cell Physiol. 278: C17–C25, 2000.— Some amphipathic bitter tastants and non-sugar sweeteners are direct activators of G proteins and stimulate transduction p...

P. BROWNBILL,1 D. MAHENDRAN,2 D. OWEN,3 P. SWANSON,4 K. L. THORNBURG,5 D. M. NELSON,6 AND C. P. SIBLEY1,7 Academic Unit of 1Child Health, 2Obstetrics and Gynaecology and 7School of Biological Sciences, 3Radioimmunoassay Laboratory, St. Mary’s Hospital, Manchester, M13 0JH United Kingdom; 5Department of Physiology, Oregon Health Sciences University, School of Medicine, Portland, Oregon 97201; an...

Spaanderman, M. E. A., M. Meertens, M. Van Bussel, T. H. A. Ekhart, and L. L. H. Peeters. Cardiac output increases independently of basal metabolic rate in early human pregnancy. Am J Physiol Heart Circ Physiol 278: H1585–H1588, 2000.—Early pregnancy is characterized by the institution of a high-flow low-resistance circulation. In this study, we tested the hypothesis that these hemodynamic chan...

Olsen, Henrik, Einar Vernersson, and Toste Länne. Cardiovascular response to acute hypovolemia in relation to age. Implications for orthostasis and hemorrhage. Am. J. Physiol. Heart Circ. Physiol. 278: H222–H232, 2000.— Venous compliance in the legs of aging man has been found to be reduced with decreased blood pooling (capacitance response) in dependent regions, and this might lead to misinter...