Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1-ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration. By contrast, in cells expressing plexin-B1 and Met, ligand stimulation results in an association wi...

I a comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al. (1) provide evidence in this issue of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. B1 receptors are generally silent or absent in healthy states and are induced or activated by pathological challenges. When they are absent, as in B1-KO mice, ti...

An interesting method for B1 mapping based on the Bloch-Siegert (BLS) shift was recently presented (1,2) for gradient echo (FLASH) and Spin Echo (SE) sequences. This method uses off-resonant pulses before signal acquisition to encode the B1 information into the signal phase. Fast B1 mapping is possible since the repetition time has only minor influence on the quality of the phase information. I...

3,700,820 A 10/1972 Blasbalg et a1. 6,385,329 B1 5/2002 Sharma et a1. 6,580,694 B1 6/2003 Baker 6,584,125 B1 6/2003 Katto 6,728,678 B2 4/2004 Bhadkamkar et 211. 6,754,203 B2 6/2004 Wah et a1. 6,868,094 B1 3/2005 Bordonaro et a1. 6,956,871 B2 * 10/2005 Wang et a1. ................. .. 370/503 7,061,938 B2 6/2006 Hogeboom 7,260,220 B2 8/2007 Steenhof et a1. 7,295,578 B1 11/2007 Lyle et a1. 7,333,...

where x ∈ R is represents the variables, c ∈ R defines the objective function, and A ∈ Rm×n and b ∈ R define the constraints. The above form is fairly general; one can model various types of constraints in this form. For example, a constraint 〈a1, x〉 ≥ b1 can be written as 〈−a1, x〉 ≤ −b1. Or, a constraint 〈a1, x〉 = b1 can be written as 〈a1, x〉 ≤ b1 and 〈−a1, x〉 ≤ −b1. The objective function can...

Cyclin genes and their products are important regulatory participants in the eukaryotic cell cycle. It is well established that cyclin B1 protein forms a complex with cyclin-dependent kinase 1 (CDK1), which, when activated, initiates mitosis. We have previously established that cyclin B1 gene expression is posttranscriptionally regulated in regenerating rat liver after 70% partial hepatectomy (...

Heterogeneous nuclear ribonucleoprotein (hnRNP) B1 is a RNA-binding protein of Mr 37,000. We previously reported that hnRNP B1 was specifically overexpressed in the nuclei of human lung cancer cells, particularly in squamous cell carcinoma (E. Sueoka et al., Cancer Res., 59: 1404-1407, 1999). We extended this study to determine whether hnRNP BL was overexpressed in roentgenographically occult c...

Abel’s identity a1b1+a2b2+· · ·+ambm = (b1+b2+· · ·+bm)am+(b1+· · ·+bm−1)(am−1−am)+· · ·+b1(a1−a2) is used to give a refinement of a recent theorem of Sellers.