BACKGROUND This prospective cohort study aimed to investigate single and additive effects of health behaviours for risk of future disability pension (DP) due to musculoskeletal diagnoses, DP due to mental diagnoses, DP due to circulatory system diagnoses or DP due to other diagnoses. A secondary aim was to evaluate the role of familial confounding in these associations. METHODS A sample of 31...

Diabetes-prone (DP) BioBreeding (BB) rats develop spontaneous autoimmune diabetes. DP-BB thymocyte export is reduced, and most thymic emigrants disappear rapidly from peripheral lymphoid tissues. DP-BB rats are consequently lymphopenic and circulate severely reduced numbers of T cells. Peripheral T cells present are phenotypically immature (Thy1+) and appear activated. We hypothesized that DP-B...

Specific interactions between desmoplakins I and II (DP I and II) and other desmosomal or cytoskeletal molecules have been difficult to determine in part because of the complexity and insolubility of the desmosome and its constituents. We have used a molecular genetic approach to investigate the role that DP I and II may play in the association of the desmosomal plaque with cytoplasmic intermed...

The differentiation process from CD4-CD8- double-negative (DN) thymocytes to CD4+CD8+ double-positive (DP) stage is accompanied by vigorous proliferation. The resulting DP cells contain a sizable proportion of large cycling cells, but most DP cells are small resting cells. To explore the molecular mechanisms which regulate cell proliferation of DP thymocytes prior to further development, we use...

In present study, a three-step multi-objective optimization algorithm of cyclone separators is catered for the design objectives. First, the pressure drop (Dp) and collection efficiency (h) in a set of cyclone separators are numerically evaluated. Secondly, two meta models based on the evolved Group Method of Data Handling (GMDH) type neural networks are regarded to model the Dp and h as the re...

This paper describes a new methodology for software engineering: the DP&T Methodology. It is the core component of the new DP&T System. Different from traditional methodologies with linear process models, the DP&T Methodology uses the nonlinear DP&T Model with the capacity for forward and backward traceablity. Driven by six types of automated traceability and two types of defect prevention, the...

Inulin-type fructans are the simplest and most studied fructans and have become increasingly popular as prebiotic health-improving compounds. A natural variation in the degree of polymerization (DP) of inulins is observed within the family of the Asteraceae. Globe thistle (Echinops ritro), artichoke (Cynara scolymus), and Viguiera discolor biosynthesize fructans with a considerably higher DP th...

DP-155 is a lipid prodrug of indomethacin that comprises the latter conjugated to lecithin at position sn-2 via a 5-carbon length linker. It is cleaved by phospholipase A2 (PLA)(2) to a greater extent than similar compounds with linkers of 2, 3, and 4 carbons. Indomethacin is the principal metabolite of DP-155 in rat serum and, after DP-155 oral administration, the half-life of the metabolite w...

The activity of antimetabolite inhibitors of de novo deoxyribonucleotide biosynthesis can be compromised by the salvage of extracellular preformed nucleosides and nucleobases. Dipyridamole (DP) is a nucleoside transport inhibitor that has been used clinically in an attempt to increase antimetabolite activity; however, DP binds tightly to the serum protein alpha1-acid glycoprotein (AGP) thereby ...