The medullary ventral respiratory column (VRC) of neurons is essential for respiratory motor pattern generation; however, the functional connections among these cells are not well understood. A rostral extension of the VRC, including the retrotrapezoid nucleus/parafacial region (RTN-pF), contains neurons responsive to local perturbations of CO(2)/pH. We addressed the hypothesis that both local ...

Platelet factor 4 (PF-4) is a member of the chemokine family with powerful antiangiogenic properties. The mechanism by which PF-4 inhibits endothelial cell proliferation is unclear. We investigated the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast growth factor (FGF2). We found that PF-4 (10 microg/mL) inhibited the FGF2-induced proliferation of adrenal co...

BACKGROUND Available information about the association between education and physical fitness (PF) is scarce. The purpose of this study was to examine educational differences in PF in the working age population using different methods to assess PF. METHODS The Health 2000 Survey was carried out for adults aged ≥ 30 years (n = 8028) in Finland. For this study, 30-54-year-old men and women with...

Phase-feeding (PF; Treatment 2) was tested relative to an NRC regimen (Treatment 1) to evaluate the impact of PF on broilers during the finisher period (42 to 63 d). Two modified PF treatments were also tested during this experiment: Treatment 3 involved lowering the amino acid requirements predicted with PF linear regression equations by 10% (PF10), Treatment 4 involved increasing the slope of...

In order to study the thermal stability of accelerated-curing PF resin, the curing behavior of fresh PF resin was investigated in the presence of single accelerator of methylolurea derivatives (MMU), magnesium hydrate (Mg(OH)2), 25% aqueous solution of sodium carbonate (Na2CO3), and propylene carbonate (PC). Also their optimum combination was added in fresh PF resin. The thermal stability of cu...

BACKGROUNDS/AIMS Few reports have validated the clinical postoperative pancreatic fistula (PF) after distal pancreatectomy. The study intended to validate the predictability for clinical PF of drain amylase and lipase and to find out more appropriate postoperative day (POD) for diagnostic criterion of PF. METHODS A total of 154 patients underwent distal pancreatectomy. We used the clinical da...

BACKGROUND As a serine/threonine protein kinase, p70S6K plays an important role in tumor cells. Evidence has revealed overexpression of p70S6K and phosphorylated p70S6K (p-p70S6K) in various tumor tissues, with these proteins identified as independent prognostic markers in non-small cell lung cancer (NSCLC). In this study, we explored the role of the p70S6K specific inhibitor PF-4708671 in NSCL...

Two trials were conducted to study the effect of multi-steps phase-feeding (PF) program on growth performance of broiler chickens from 1 to 24 and 1 to 39 d of age. The control group was the nutrient recommendation of Aviagen (2019) with a three-step PF program (1-10, 11-24 and 25-39 d of age). In the first trial, the control group was compared with an eight-step PF program (PF8), and in the se...

The platelet factor-4 variant, designated PF-4var/CXCL4L1, is a recently described natural non-allelic gene variant of the CXC chemokine platelet factor-4/CXCL4. PF-4var/CXCL4L1 was cloned, and the purified recombinant protein strongly inhibited angiogenesis. Recombinant PF-4var/CXCL4L1 was angiostatically more active (at nanomolar concentration) than PF-4/CXCL4 in various test systems, includi...