نتایج جستجو برای: فاکتور القاکنندۀ هایپوکسی hif

تعداد نتایج: 23880  

2009
David R. Mole Christine Blancher Richard R. Copley Patrick J. Pollard Jonathan M. Gleadle Jiannis Ragoussis Peter J. Ratcliffe

Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia. To better understand this transcriptional cascade we performed genome-wide chromatin immunoprecipitation using antibodies to two major HIF-alpha subunits, and correlated the results with genome-wide transcript profiling. Within a tiled promoter array we identified 546 and 143 sequences that bound, respe...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Maija Hirsilä Peppi Koivunen Leon Xu Todd Seeley Kari I Kivirikko Johanna Myllyharju

Hypoxia-inducible transcription factor (HIF) is regulated by two oxygen-dependent events that are catalyzed by the HIF prolyl 4-hydroxylases (HIF-P4Hs) and HIF asparaginyl hydroxylase (FIH). We have purified the three recombinant human HIF-P4Hs to near homogeneity and characterized their catalytic properties and inhibition and those of FIH. The specific activities of the HIF-P4Hs were at least ...

Journal: :International Journal of Molecular Sciences 2021

In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between excessive production reactive oxygen species (ROS) and a lowering antioxidant production. Moreover, has been shown to inhibit Sirtuin 1 (SIRT1), which able prevent hypoxia-inducible factor (HIF)-1α stabilization. The...

Journal: :Journal of Kidney Cancer and VHL 2021

Hypoxia-inducible factor (HIF), an important mediator of hypoxia response, is implicated in tumorigenesis the setting pseudohypoxia, such as inactivation von Hippel–Lindau tumor suppressor protein (pVHL), leading to development and progression clear cell renal carcinoma (ccRCC). Targeting downstream molecules HIF pathway, vascular endothelial growth (VEGF), has led improvement clinical outcome ...

Journal: :Investigative ophthalmology & visual science 2005
Kan Ding Marzia Scortegagna Robyn Seaman David G Birch Joseph A Garcia

PURPOSE To characterize ocular disease in HIF-2alpha-null mice. METHODS Histologic, electroretinographic (ERG), and molecular studies were performed on samples obtained from age- and gender-matched HIF-2alpha-null (HIF-2alpha-KO), HIF-2alpha-heterozygous (HIF-2alpha-HET), and wild-type (WT) littermate mice. RESULTS HIF-2alpha-KO mice exhibited marked thinning of the retina and abnormal reti...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Nicola J Mabjeesh Margaret T Willard Carrie E Frederickson Hua Zhong Jonathan W Simons

PURPOSE Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates VEGF expression through the activation of the transcriptional factor, hypoxia-inducible factor 1 (HIF-1). We tested the hypothesis that an effect of androgens on VEGF expression is regulated direct...

ژورنال: مجله پژوهش سلامت 2019
Mohammadi, Mohammad Taghi, Norooz Zade, Ali, Shahyad, Shima, Vahidi, Hadi,

Peroxisome proliferator-activated receptor alpha (PPAR-α), which belongs to the nuclear receptor family of ligand-activated transcription factors, was first described as gene regulators for metabolic pathways including lipid metabolism, insulin sensitivity, and glucose homeostasis. Were raised. This nuclear receptor is widely expressed in various tissues, providing a wide range of effects to st...

Journal: :Molecular bioSystems 2015
I N Mistry P J S Smith D I Wilson A Tavassoli

HIF-1 is the master regulator of cellular hypoxia response; the oxygen sensitive HIF-1α subunit transactivates its own expression in hypoxia via a hypoxia response element (HRE) in the promoter of the HIF-1α gene. This transactivation loop significantly contributes to the build up of HIF-1α at the onset of hypoxia, with the binding of HIF-1 to the HIF-1α promoter being dependent on the epigenet...

2014
Véronique N. Lafleur Stéphane Richard Darren E. Richard

Hypoxia-inducible factors (HIF-1 and HIF-2) are essential mediators for the adaptive transcriptional response of cells and tissues to low-oxygen conditions. Under hypoxia or when cells are treated with various nonhypoxic stimuli, the active HIF-α subunits are mainly regulated through increased protein stabilization. For HIF-1α, it is clear that further transcriptional, translational, and posttr...

Journal: :Oncology reports 2014
Juan Ma Li Zhuo Han He Liang Chunliu Mi Hui Shi Jung Joon Lee Xuejun Jin

Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology. In a search for HIF-1 inhibitors, we identified celastrol as an inhibitor of HIF-1 activation from Tripterygium wilfordii. In the present study, we demonstrated the effect of celastrol on HIF-1 activation. Celastrol showed a potent inhibitory activity again...

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