The paper presents a model for simulating the protein folding process in silico. The two-step model (which consists of the early stage-ES and the late stage-LS) is verified using two proteins, one of which is treated (according to experimental observations) as the early stage and the second as an example of the LS step. The early stage is based solely on backbone structural preferences, while t...

Levosimendan (LS), a Ca(2+) sensitizer, is presently limited to i.v. administration. The dose-related pharmacodynamic effects of newly developed oral LS remain undetermined. We assessed the dose-response relationship of oral LS in nine normal and seven pacing-induced heart failure (HF), conscious, chronically instrumented mongrel dogs. Animals received a placebo capsule on day 1, and then LS wa...

about release-modulating receptors at noradrenergic axon terminals. Receptors for angiotensin, acetylcholine, prostaglandins, opioids, and adrenergic agents are discussed separately, followed by general problems such as the cellular mechanism of modulation and the general significance of presynaptic receptors. [The SCV’ indicates that this paper has been cited in over 1,035 publications, making...

 We investigate the existence of some‎ ‎large sets of size nine‎. ‎The large set $LS[9](2,5,29)$ is constructed and‎ ‎existence of the family $LS[9](2,5,27l+j)$ for $lgeq 1, ‎2leq‎ ‎j

HYPOTHESIS Laparoscopic splenectomy (LS) provides health benefits to patients compared with open splenectomy (OS) in terms of perioperative morbidity, complications, and patient recuperation. DESIGN Prospective operative and outcome data of LS patients were compared with those of OS patients (historical controls). SETTING Data were gathered, and patients were evaluated and treated at 2 McMa...

BACKGROUND The myocardial wall of the left ventricle is a complex, multilayered structure and is not homogenous. The aim of this study was to determine longitudinal strain (LS) in the three myocardial layers in normal pregnant women according to gestation proceedings. METHODS The advanced two-dimensional speckle tracking echocardiography (2D STE) was performed on 62 women during each pregnanc...

[1] Eddy diffusivities in the Labrador Sea (LS) are estimated from deep eddy resolving float trajectories, moored current meter records, and satellite altimetry. A mean residence time of 248 days in the central LS is observed with several floats staying for more than 2 years. By applying a simple random walk diffusion model, the observed distribution of float residence times in the central LS c...

We study the Lovász-Schrijver lift-and-project operator (LS+) based on the cone of symmetric, positive semidefinite matrices, applied to the fractional stable set polytope of graphs. The problem of obtaining a combinatorial characterization of graphs for which the LS+-operator generates the stable set polytope in one step has been open since 1990. We call these graphs LS+-perfect. In the curren...

OBJECTIVE Patients with Laron syndrome (LS; primary GH insensitivity) caused by molecular defects of the GH receptor gene, are characterized by dwarfism, profound obesity, and hyperlipidemia. The aim of the current study was to evaluate adiponectin levels in LS, as obesity is known to be associated with low adiponectin. DESIGN AND METHODS We studied nine untreated LS adult patients (5 males, ...