A monoclonal antibody (mAb) that recognizes the y chain of human fetal hemoglobin(Hb F) has been produced by cell hybridization techniques. The mAb reacts with Hb F (a2y2), Hb Bail’s(y),and Hb Kenya (yhybrid), butdoes notcrossreactwith Hb A (a) or Hb A2 (a2&). We describe a direct enzyme-linked immunoassay (ELISA)for measurement of Hb F, in which hemoglobins from standards or from unknown hemol...

كان لسياسة النظام البعثي في ​​العراق أثر كبير ظهور وتوسع الأحزاب والحركات المعارضة للنظام ، خاصة بعد الغزو العراقي للكويت وقيام الانتفاضة الشعبانية والأساليب القمعية التي مارسها مع الشعب المعارض. كانت ضعيفة داخليا ولم تكن موحدة بل هناك اتجاهات مختلفة مما أضعف موقفها الداخل، وعلى الصعيد الدولي فضلا عن رفض لأي شكل من أشكال المعارضة، لذلك عامل الاحزاب بقسوة ووحشية، اضعفها بشكل كبير، ناهيك تدخل دور...

CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist. We demonstrate that Hb interacts efficiently with CD163 in the absence of Hp. Not only is Hb internalized into an endosomal compartment by CD163 as a result of active receptor...

Studies were carried out during the postnatal period in infants born at or before the 32nd wk of gestation to determine the proportion of fetal hemoglobin (Hb F) and adult hemoglobin (Hb A) being synthesized, and to compare these studies to those previously reported on at birth from normal newborn infants 25-43 wk gestation. When the pretern infants reached the postconceptional age correspondin...

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. Here, we show that HB-EGF-EGFR signaling is involved in eyelid development. HB-EGF expression is restricted to the tip of the leading edge of the migrating epithelium during eyelid closure in late gestation mouse embryos. Both HB-EGF null...

Heparin-binding EGF-like growth factor (HB-EGF) is a smooth muscle cell mitogen composed of both EGF receptor and heparin-binding domains. To better understand the function of its domains, intact HB-EGF or its heparin-binding (HB) domain (amino acids 1-45) were fused to a mutant Pseudomonas exotoxin with an inactivated cell-binding domain. The resulting chimeric toxins, HB-EGF-PE* and HB-PE*, w...

Hemoglobin (Hb) is the major protein in erythrocytes and carries oxygen (O2) throughout the body. Recently, Hb has been found synthesized in atypical sites, including the brain. Hb is highly expressed in A9 dopaminergic (DA) neurons of the substantia nigra (SN), whose selective degeneration leads to Parkinson's disease (PD). Here we show that Hb confers DA cells' susceptibility to 1-methyl-4-ph...

Hb E-Saskatoon and Hb G-Coushatta are rare hemoglobin variants that are not a health problem. Herein we present a Turkish woman that was diagnosed as homozygous Hb E-Saskatoon (only the second such case reported from Turkey) and a Turkish boy diagnosed as heterozygote Hb E-Saskatoon. Additionally, 2 Turkish sisters diagnosed as heterozygote Hb G-Coushatta are presented.

Hemoglobins (Hb) Yakima and Kempsey were purified from patients' blood with diethylaminoethyl cellulose column chromatography. The oxygen equilibrium curves of the two hemoglobins and the effects of organic phosphates on the function were investigated. In 0.1 M phosphate buffer, Hill's constants n for Hb Yakima and Hb Kempsey were 1.0 to 1.1 at the pH range for 6.5 to 8.0 and the oxygen affinit...

Hemoglobin Crete, 1 29 (H7) ala -k pro, is #{149} new mutant hemoglobin (Hb) with high oxygen affinity that was discovered in a Greek family in various combinations with #{176}and #{244} ’-thaIassemia. The propositus. who presented an unusual clinical picture of an “overcompenseted” hemolytic state. with erythrocytosis. splenomegaly. abnormal red cell morphology, and marked erythroid hyperplasi...