User-generated content has been ubiquitous on the Internet. This paper studies the e ect of user-generated content on competing rms' product design decisions when they face uncertain consumer taste. User-generated content makes rms better informed about consumer taste because of the additional information revealed, and it also makes their information more correlated because user-generated conte...

Rhabdomyosarcoma (RMS), which represents the most frequent soft tissue sarcoma in pediatric populations, is classified into two major subtypes: embryonal RMS (ERMS) and alveolar RMS (ARMS). ARMS subtype, which shows greater aggressiveness and proneness to metastasis with respect to ERMS, are characterized, in about 75% of cases, by specific chromosomal translocations that involve PAX and FOXO1 ...

Multidrug resistance (MDR) is a common problem in the treatment of childhood rhabdomyosarcoma (RMS). A complete reversal of MDR is currently not possible. The aim of this study was to investigate the role of glutathione-S-transferase (GST) as mechanism of MDR in childhood RMS and to analyze possible reversal strategies. Female athymic mice underwent xenotransplantation with embryonal or alveola...

This paper reviews the development of a root mean squared error (RMS) flaw sizing criterion. The effect of using an RMS error criterion for the sizing performance of the PISC II [1-3] inspection teams is investigated. A crucial part of establishing an RMS error sizing criterion is the decomposition of the components in the RMS error into the sum of the squares of the mean error, the standard er...

This paper explains the rationale for the development of reconfigurable manufacturing systems, which possess the advantages both of dedicated lines and of flexible systems. The paper defines the core characteristics and design principles of reconfigurable manufacturing systems (RMS) and describes the structure recommended for practical RMS with RMS core characteristics. After that, a rigorous m...

A difference of approximately 5 dB exists between the level of spoken English determined using the ANSI standard vu-meter method compared to the common root-mean-square (rms) method. If the rms method is substituted for the present ANSI standard method for calibrating a speech audiometer, for example, the reported speech reception thresholds will improve 5 dB: Speech levels read approximately 5...

We study the investment and nancing policies of public U.S. rms. Large rms substitute between debtand equity nancing over the business cycle whereas small rms' nancing policy for debt and equity is pro-cyclical. This paper proposes a novel mechanism that explains these cyclical patterns in a quantitative heterogeneous rm industry model with endogenous rm dynamics. We nd that cross-sectional di ...

Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression but are unable to terminally differentiate. The Notch signaling pathway is a master player durin...

We focus on a relatively neglected area of the tax-compliance literature in economics, the behaviour of rms. We examine the impact of alternative audit rules on receipts from a tax on pro ts in the context of strategic interdependence of rms. In the market rms may compete in terms of either output or price. The enforcement policy can have an e ect on rms' behaviour in two dimensions { their mar...

Rhabdomyosarcomas (RMS) are aggressive childhood soft-tissue malignancies deriving from mesenchymal progenitors that are committed to muscle-specific lineages. Despite the histopathological signatures associated with three main histological variants, termed embryonal, alveolar and pleomorphic, a plethora of genetic and molecular changes are recognized in RMS. Over the years, exposure to carcino...