1 Public Health Foundation of India, New Delhi, India, 2 School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa, 3Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4Ghana Health Service/University of Ghana School of Public Health, Accra, Ghana, 5 School of Public Health, Makerere University...

A40 Persistent circulation of highly divergent HIV-1M lineages in the Congo Basin Region M. Tongo, J.R. Dorfman, Tulio de Oliveira, D.P. Martin, Africa Centre for Population Health, University of KwaZulu-Natal, South Africa, Division of Computational Biology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, Institute of Medical Research and Stud...

Center for Macroecology, Evolution and Climate, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark, Department of Biogeography and Global Change, National Museum of Natural Sciences, CSIC, Calle José Gutierrez Abascal 2, 28006 Madrid, Spain, InBio/CIBIO, University of Évora, Largo dos Colegiais, 7000 Évora, Portugal, Metapopulation Research Centre, Department of Bioscienc...

BACKGROUND Propolis and its major constituent - caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in inflammatory microenvironment, and inflammatory responses play decisive roles at different stages of tumor development. To understand the effects and mechanisms of ethanol-extracted...

1Centre for Human Metabonomics, North-West University, Potchefstroom, South Africa; 2Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa; 3Department of Clinical Laboratory Sciences, Division of Human Genetics & Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town,...

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable disease. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory , anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In t...

Caffeic acid phenethyl ester (CAPE), which is derived from the propolis of honeybee hives, has been shown to reveal anti-inflammatory properties. Since T-cells play a key role in the onset of several inflammatory diseases, we have evaluated the immunosuppressive activity of CAPE in human T-cells, discovering that this phenolic compound is a potent inhibitor of early and late events in T-cell re...

Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar co...

BACKGROUND Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new applications have been investigated. The present study aimed to investigat...

Hyperthermal stress and resulting free radical generation is known to impair endurance capacity and immune cell redistribution during prolonged exercise. Caffeic acid phenethyl ester (CAPE), a phenolic compound purified from propolis, has many biological and pharmacological activities including antioxidation. To examine whether CAPE has protective effect against hyperthermal stress in athletes,...