2014 The anchoring strength coefficient B is measured as a function of temperature using a Freedericksz technique in a very thin (l 2.5 03BCm) surfactant-treated cell of methoxybenzylidene butylaniline (MBBA). In the nematic phase this parameter varies from approximately 0.065 to 0.013 erg/cm2 for TNI 20 °C T TNI. The relationship between B and the nematic order parameter is discussed. J. Physi...

We report the determination of the Kerr constant (B) and the real part of the third-order nonlinear optic susceptibility (chi(3)) above the nematic-isotropic phase transition temperature (TNI) of a liquid crystal composed of bent-shaped molecules. The values of B and chi(3) just above (approximately 0.3 degrees C) TNI are approximately 8x10(-12) m/V2 and 5x10(-20) m2/V2, respectively. The estim...

We have analyzed one of the nine complementation groups that constitute the haplolethal (HL) region of the Shaker gene complex (ShC). Five mutations, including a dominant lethal, define this complementation group: HL I. Mutant phenotypes show abnormal embryogenesis with structural defects in the nervous system and aberrant degeneration of specific adult muscles in addition to altered action pot...

Impaired muscle function (fatigue) may result, in part, from modification of contractile proteins due to inadequate O(2) delivery. We hypothesized that severe hypoxemia would modify skeletal troponin I (TnI) and T (TnT), two regulatory contractile proteins, in respiratory muscles. Severe isocapnic hypoxemia (arterial partial pressure of O(2) of approximately 25 Torr) in six pentobarbital sodium...

Troponin is the key component of the calciumdependent switch of the contractile apparatus in striated muscle. There are three subunits of troponin: troponin C, a Ca -binding calmodulin-like protein; troponin T, which attaches the complex to tropomyosin, anchoring it to the thin filament as well as having a regulatory role; and troponin I (TnI), named for its ability to inhibit actin-myosin inte...

We investigated the mechanism(s) responsible for differences in the effects of acidic pH on Ca2' activation of the activity of adult and neonatal rat heart myofilaments. Studies on preparations of myofilaments reconstituted with adult troponin-tropomyosin (Tn-Tm) and either adult or neonatal thick filaments indicated that the difference in effect of acidic pH is related to differences in Tn-Tm ...

Activation of cAMP-dependent protein kinase A (PKA) in ventricular myocytes by isoproterenol (Iso) causes phosphorylation of both phospholamban (PLB) and troponin I (TnI) and accelerates relaxation by up to twofold. Because PLB phosphorylation increases sarcoplasmic reticulum (SR) Ca pumping and TnI phosphorylation increases the rate of Ca dissociation from the myofilaments, both factors could ...

BACKGROUND This randomized, controlled trial assessed the impact of a tailored navigation intervention versus a standard mailed intervention on colorectal cancer screening adherence and screening decision stage (SDS). METHODS Primary care patients (n = 945) were surveyed and randomized to a Tailored Navigation Intervention (TNI) Group (n = 312), Standard Intervention (SI) Group (n = 316), or ...