نتایج جستجو برای: سیستم ترمیم mmr
تعداد نتایج: 81302 فیلتر نتایج به سال:
OBJECTIVE Maternal mortality reduction is a Millennium Development Goal. In Colombia, there is a large disparity in the maternal mortality ratio (MMR) between and into departments (states) and also between municipalities. We examined socioeconomics variables at the municipal and departmental levels which could be associated to the municipal maternal mortality in Colombia. METHODS A multilevel...
زمینه و هدف: یکی از روش های پیشگیری از بیماریهای عفونی، ایمن سازی می باشد که هدف کوتاه مدت آن مهار بیماری در افراد و هدف نهایی آن ریشه کن کردن بیماری است. از آنجایی که واکسن ها دارای عوارضی هستند و تاکنون آمار دقیقی در مورد میزان بروز عوارض واکسیناسیون در بجنورد موجود نیست، لذا کسب اطلاعات در موردعوارض واکسیناسیون میتواند مبنایی برای برنامه ریزی های بهداشتی و بهبود آن باشد. مواد و روش کار: در م...
زمینه و هدف: واکسن سرخک، اوریون و سرخجه ( (mmrازسال 1383 به برنامه واکسیناسیون اطفال ایران افزوده شد و تا کنون مطالعات کافی و قابل توجهی در زمینه واکنش های جانبی آن در ایران انجام نشده است. این مطالعه به منظور تعیین واکنش های جانبی این واکسن که انتظار می رود در طول یک ماه بعد از تزریق در کودکان رخ دهند، صورت گرفت. روش کار: این پژوهش یک مطالعه توصیفی- مقطعی می باشد که بر روی 210 کودک واکسینه شده...
Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antib...
Colorectal cancer (CRC) is prevalent worldwide, and treatment often involves surgery and genotoxic chemotherapy. DNA repair mechanisms, such as base excision repair (BER) and mismatch repair (MMR), may not only influence tumour characteristics and prognosis but also dictate chemotherapy response. Defective MMR contributes to chemoresistance in colorectal cancer. Moreover, BER affects cellular s...
Impaired mismatch repair (MMR) is reportedly crucial in the early stages of endometrial carcinogenesis. Although estrogen exposure is considered an important risk factor for endometrial carcinoma, the relationship between estrogen and MMR activity remains undetermined. The present study was undertaken to elucidate the effect of estrogen on MMR activity in normal and malignant endometrial cells....
Mice lines homozygous negative for one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, PMS2, MSH6) were generated as models for MMR deficient (MMR-D) diseases. Clinically, hereditary forms of MMR-D include Lynch syndrome (characterized by a germline MMR gene defect) and constitutional MMR-D, the biallelic form. MMR-D knockout mice may be representative for both diseases. Here, we aimed...
BACKGROUND There is evidence that colorectal cancers (CRC) with DNA mismatch repair deficiency (MMR-D) are associated with a better prognosis than the generality of large bowel malignancies. Since an active immune surveillance process has been demonstrated to influence CRC outcome, we investigated whether MMR-D can enhance the immune response in CRC. PATIENTS AND METHODS A group of 113 consec...
PURPOSE Microsatellite instability (MSI) is found in 10% to 15% of sporadic colorectal tumors and is usually caused by defects in DNA mismatch repair (MMR). In 1997, a panel of microsatellite markers including mononucleotide and dinucleotide repeats was recommended by a National Cancer Institute workshop on MSI. We investigated the relationship between instability of these markers and MMR prote...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید